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Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer.

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Title: Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer.
Authors: Liao Y; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Yang R; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Wang B; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Ruan Y; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Cui L; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Yang J; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Yu X; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Han S; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Yao Y; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Luan X; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Li Y; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Shi M; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China., Li S; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, China. shuijie.li@hrbmu.edu.cn.; Heilongjiang Province Key Laboratory of Research on Molecular Targeted Anti-Tumor Drugs, Harbin, China. shuijie.li@hrbmu.edu.cn., Liu C; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China. liuchao@hrbmu.edu.cn.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China. liuchao@hrbmu.edu.cn.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China. liuchao@hrbmu.edu.cn., Zhang Y; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China. yanqiaozhang@ems.hrbmu.edu.cn.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China. yanqiaozhang@ems.hrbmu.edu.cn.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China. yanqiaozhang@ems.hrbmu.edu.cn.
Source: Oncogene [Oncogene] 2025 Apr; Vol. 44 (14), pp. 944-957. Date of Electronic Publication: 2024 Dec 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
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  Data: Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Liao+Y%22">Liao Y</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Ruan+Y%22">Ruan Y</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Cui+L%22">Cui L</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yao+Y%22">Yao Y</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Luan+X%22">Luan X</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, China. shuijie.li@hrbmu.edu.cn.; Heilongjiang Province Key Laboratory of Research on Molecular Targeted Anti-Tumor Drugs, Harbin, China. shuijie.li@hrbmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China. liuchao@hrbmu.edu.cn.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China. liuchao@hrbmu.edu.cn.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China. liuchao@hrbmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China. yanqiaozhang@ems.hrbmu.edu.cn.; Key Laboratory of Tumor Immunology in Heilongjiang, Harbin, China. yanqiaozhang@ems.hrbmu.edu.cn.; Clinical Research Center for Colorectal Cancer in Heilongjiang, Harbin, China. yanqiaozhang@ems.hrbmu.edu.cn.
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