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Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma.

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Title: Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma.
Authors: Paczkowska J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Tang M; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Astra Zeneca, Waltham, MA, USA., Wright KT; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Song L; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomedical Data Science, Dartmouth College, Hanover, NH, USA., Luu K; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; PathAI, Boston, MA, USA., Shanmugam V; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Welsh EL; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Weirather JL; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Besson N; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Olszewski H; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Porter BA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Redd RA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Cader FZ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; AstraZeneca, City House, Cambridge, UK., Mandato E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ouyang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Mechanisms of Cancer Resistance Thematic Center, Bristol Myers Squibb, Cambridge, MA, USA., Calabretta E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bai G; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA., Lawton LN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Armand P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rodig SJ; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Liu XS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, USA.; GV20 Therapeutics, LLC, Cambridge, MA, USA., Shipp MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Margaret_Shipp@dfci.harvard.edu.
Source: Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10740. Date of Electronic Publication: 2024 Dec 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma.
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  Data: <searchLink fieldCode="AU" term="%22Paczkowska+J%22">Paczkowska J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tang+M%22">Tang M</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Astra Zeneca, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wright+KT%22">Wright KT</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Song+L%22">Song L</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomedical Data Science, Dartmouth College, Hanover, NH, USA.<br /><searchLink fieldCode="AU" term="%22Luu+K%22">Luu K</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; PathAI, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shanmugam+V%22">Shanmugam V</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Welsh+EL%22">Welsh EL</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weirather+JL%22">Weirather JL</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Besson+N%22">Besson N</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Olszewski+H%22">Olszewski H</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Porter+BA%22">Porter BA</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pfaff+KL%22">Pfaff KL</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Redd+RA%22">Redd RA</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cader+FZ%22">Cader FZ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; AstraZeneca, City House, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mandato+E%22">Mandato E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ouyang+J%22">Ouyang J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Mechanisms of Cancer Resistance Thematic Center, Bristol Myers Squibb, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Calabretta+E%22">Calabretta E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bai+G%22">Bai G</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lawton+LN%22">Lawton LN</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Armand+P%22">Armand P</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rodig+SJ%22">Rodig SJ</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+XS%22">Liu XS</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, USA.; GV20 Therapeutics, LLC, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shipp+MA%22">Shipp MA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Margaret_Shipp@dfci.harvard.edu.
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