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NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.

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Title: NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.
Authors: Reddy T; Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.; Houston Methodist Research Institute, Houston, TX, USA.; Houston Methodist Neal Cancer Center, Houston, TX, USA., Puri A; Houston Methodist Research Institute, Houston, TX, USA.; Houston Methodist Neal Cancer Center, Houston, TX, USA., Guzman-Rojas L; Houston Methodist Research Institute, Houston, TX, USA., Thomas C; Houston Methodist Research Institute, Houston, TX, USA.; Houston Methodist Neal Cancer Center, Houston, TX, USA., Qian W; Houston Methodist Research Institute, Houston, TX, USA., Zhou J; Houston Methodist Research Institute, Houston, TX, USA., Zhao H; Houston Methodist Research Institute, Houston, TX, USA.; Houston Methodist Neal Cancer Center, Houston, TX, USA., Mahboubi B; Adams School of Dentistry, University of North Carolina, Chapel Hill, USA., Oo A; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA., Cho YJ; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA., Kim B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA., Thaiparambil J; Houston Methodist Research Institute, Houston, TX, USA., Rosato R; Houston Methodist Research Institute, Houston, TX, USA., Martinez KO; Houston Methodist Research Institute, Houston, TX, USA., Chervo MF; Houston Methodist Research Institute, Houston, TX, USA., Ayerbe C; McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA., Giese N; Houston Methodist Research Institute, Houston, TX, USA.; Houston Methodist Neal Cancer Center, Houston, TX, USA., Wink D; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD, USA., Lockett S; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Wong S; Houston Methodist Research Institute, Houston, TX, USA.; Houston Methodist Neal Cancer Center, Houston, TX, USA., Chang J; McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Krishnamurthy S; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yam C; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Moulder S; Eli Lilly and Company, Indianapolis, IN, USA., Piwnica-Worms H; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Meric-Bernstam F; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang J; Houston Methodist Research Institute, Houston, TX, USA. jcchang@houstonmethodist.org.; Houston Methodist Neal Cancer Center, Houston, TX, USA. jcchang@houstonmethodist.org.
Source: Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10737. Date of Electronic Publication: 2024 Dec 30.
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.
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