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A machine learning approach identifies cellular senescence on transcriptome data of human cells in vitro.

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Title: A machine learning approach identifies cellular senescence on transcriptome data of human cells in vitro.
Authors: Mahmud S; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA., Zheng C; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China., Santiago FE; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA., Zhang L; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA., Dong X; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA. dong0265@umn.edu.; Department of Genetics, Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA. dong0265@umn.edu.
Source: GeroScience [Geroscience] 2025 Jun; Vol. 47 (3), pp. 5287-5301. Date of Electronic Publication: 2024 Dec 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mahmud+S%22">Mahmud S</searchLink>; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.<br /><searchLink fieldCode="AU" term="%22Santiago+FE%22">Santiago FE</searchLink>; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; Institute on the Biology of Aging and Metabolism, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA. dong0265@umn.edu.; Department of Genetics, Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, MN, 55455, USA. dong0265@umn.edu.
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        Value: 10.1007/s11357-024-01485-6
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              Text: 2025 Jun
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