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Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy.

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Title: Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy.
Authors: Poumeaud F; Department of Medical Oncology, Oncopole Claudius Regaud, Toulouse, France; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France., Valentin T; Department of Medical Oncology, Oncopole Claudius Regaud, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France., Fares N; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France., Segier B; Biostatistics & Health Date Science Unit, Oncopole Claudius Regaud IUCT-O, Toulouse, France., Watson S; Department of Medical Oncology, Institut Curie, Paris, France., Verret B; Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France., Tlemsani C; Department of Medical Oncology, APHP, Paris, France., Penel N; Department of Medical Oncology, Centre Oscar Lambret, Lille, France., Lejeune S; Department of Oncogenetics, Lille University Hospital, Lille, France., Firmin N; Department of Medical Oncology, Institut du Cancer de Montpellier, Montpellier, France., Sabouret A; Department of Medical Oncology, Institut Curie, Paris, France., Thery JC; Department of Medical Oncology, Centre Henri Becquerel, Rouen, France., Bonvalot S; Biostatistics & Health Date Science Unit, Oncopole Claudius Regaud IUCT-O, Toulouse, France., Cottereau E; Department of Oncogenetics, Tours University Hospital, Tours, France., Cauchin E; Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Saint-Herblain, France., Lancon A; Department of Oncogenetics, Centre Georges François Leclerc, Dijon, France., Nambot S; Department of Oncogenetics, Centre Georges François Leclerc, Dijon, France., Zattara H; Department of Oncogenetics, Marseille University Hospital, Marseille, France., Coudert M; Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Saint-Herblain, France., Fourme E; Biostatistics & Health Date Science Unit, Oncopole Claudius Regaud IUCT-O, Toulouse, France., Nogues C; Department of Oncogenetics, Institut Paoli Calmettes, Marseille, France., Tougeron D; Department of Medical Oncology, Poitiers University Hospital, Poitiers, France., Prieur F; Department of Oncogenetics, Saint Etienne University Hospital, Saint Etienne, France., Collonge-Rame MA; Department of Oncogenetics, Besançon University Hospital, Besançon, France., Denis C; Department of Oncogenetics, Strasbourg University Hospital, Strasbourg, France., Laurent-Puig P; Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France., Chieze-Valero S; Department of Oncogenetics, Niort Hospital Centre, Niort, France., Dreyfus H; Department of Medical Oncology, Institut Sainte Catherine, Avignon, France., Jaffrelot M; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Department of Oncogenetics, Oncopole Claudius Regaud, Toulouse, France., Vande Perre P; Department of Oncogenetics, Oncopole Claudius Regaud, Toulouse, France., Rochaix P; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France., Gomez-Mascard A; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France., Rochefort P; Department of Oncogenetics, Centre Léon Bérard, Lyon, France; Groupe Génétique et Cancer, Unicancer, France., Campoy S; Department of Oncogenetics, Centre Léon Bérard, Lyon, France; Groupe Génétique et Cancer, Unicancer, France., Chibon F; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France., Lasset C; Department of Oncogenetics, Centre Léon Bérard, Lyon, France; Groupe Génétique et Cancer, Unicancer, France., Selves J; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France., Guimbaud R; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France; Department of Oncogenetics, Oncopole Claudius Regaud, Toulouse, France; Groupe Génétique et Cancer, Unicancer, France. Electronic address: guimbaud.r@chu-toulouse.fr.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 Feb 05; Vol. 216, pp. 115196. Date of Electronic Publication: 2024 Dec 21.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Poumeaud+F%22">Poumeaud F</searchLink>; Department of Medical Oncology, Oncopole Claudius Regaud, Toulouse, France; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Valentin+T%22">Valentin T</searchLink>; Department of Medical Oncology, Oncopole Claudius Regaud, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Fares+N%22">Fares N</searchLink>; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Segier+B%22">Segier B</searchLink>; Biostatistics & Health Date Science Unit, Oncopole Claudius Regaud IUCT-O, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Watson+S%22">Watson S</searchLink>; Department of Medical Oncology, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Verret+B%22">Verret B</searchLink>; Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Tlemsani+C%22">Tlemsani C</searchLink>; Department of Medical Oncology, APHP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Penel+N%22">Penel N</searchLink>; Department of Medical Oncology, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Lejeune+S%22">Lejeune S</searchLink>; Department of Oncogenetics, Lille University Hospital, Lille, France.<br /><searchLink fieldCode="AU" term="%22Firmin+N%22">Firmin N</searchLink>; Department of Medical Oncology, Institut du Cancer de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Sabouret+A%22">Sabouret A</searchLink>; Department of Medical Oncology, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Thery+JC%22">Thery JC</searchLink>; Department of Medical Oncology, Centre Henri Becquerel, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Bonvalot+S%22">Bonvalot S</searchLink>; Biostatistics & Health Date Science Unit, Oncopole Claudius Regaud IUCT-O, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Cottereau+E%22">Cottereau E</searchLink>; Department of Oncogenetics, Tours University Hospital, Tours, France.<br /><searchLink fieldCode="AU" term="%22Cauchin+E%22">Cauchin E</searchLink>; Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Saint-Herblain, France.<br /><searchLink fieldCode="AU" term="%22Lancon+A%22">Lancon A</searchLink>; Department of Oncogenetics, Centre Georges François Leclerc, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Nambot+S%22">Nambot S</searchLink>; Department of Oncogenetics, Centre Georges François Leclerc, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Zattara+H%22">Zattara H</searchLink>; Department of Oncogenetics, Marseille University Hospital, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Coudert+M%22">Coudert M</searchLink>; Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Saint-Herblain, France.<br /><searchLink fieldCode="AU" term="%22Fourme+E%22">Fourme E</searchLink>; Biostatistics & Health Date Science Unit, Oncopole Claudius Regaud IUCT-O, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Nogues+C%22">Nogues C</searchLink>; Department of Oncogenetics, Institut Paoli Calmettes, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Tougeron+D%22">Tougeron D</searchLink>; Department of Medical Oncology, Poitiers University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Prieur+F%22">Prieur F</searchLink>; Department of Oncogenetics, Saint Etienne University Hospital, Saint Etienne, France.<br /><searchLink fieldCode="AU" term="%22Collonge-Rame+MA%22">Collonge-Rame MA</searchLink>; Department of Oncogenetics, Besançon University Hospital, Besançon, France.<br /><searchLink fieldCode="AU" term="%22Denis+C%22">Denis C</searchLink>; Department of Oncogenetics, Strasbourg University Hospital, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Laurent-Puig+P%22">Laurent-Puig P</searchLink>; Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Chieze-Valero+S%22">Chieze-Valero S</searchLink>; Department of Oncogenetics, Niort Hospital Centre, Niort, France.<br /><searchLink fieldCode="AU" term="%22Dreyfus+H%22">Dreyfus H</searchLink>; Department of Medical Oncology, Institut Sainte Catherine, Avignon, France.<br /><searchLink fieldCode="AU" term="%22Jaffrelot+M%22">Jaffrelot M</searchLink>; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Department of Oncogenetics, Oncopole Claudius Regaud, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Vande+Perre+P%22">Vande Perre P</searchLink>; Department of Oncogenetics, Oncopole Claudius Regaud, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rochaix+P%22">Rochaix P</searchLink>; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Gomez-Mascard+A%22">Gomez-Mascard A</searchLink>; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rochefort+P%22">Rochefort P</searchLink>; Department of Oncogenetics, Centre Léon Bérard, Lyon, France; Groupe Génétique et Cancer, Unicancer, France.<br /><searchLink fieldCode="AU" term="%22Campoy+S%22">Campoy S</searchLink>; Department of Oncogenetics, Centre Léon Bérard, Lyon, France; Groupe Génétique et Cancer, Unicancer, France.<br /><searchLink fieldCode="AU" term="%22Chibon+F%22">Chibon F</searchLink>; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Lasset+C%22">Lasset C</searchLink>; Department of Oncogenetics, Centre Léon Bérard, Lyon, France; Groupe Génétique et Cancer, Unicancer, France.<br /><searchLink fieldCode="AU" term="%22Selves+J%22">Selves J</searchLink>; Toulouse Cancer Research Centre, Toulouse, France; Department of Pathology, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Guimbaud+R%22">Guimbaud R</searchLink>; Department of Digestive Medical Oncology, Toulouse University Hospital, Toulouse, France; Toulouse Cancer Research Centre, Toulouse, France; Department of Oncogenetics, Oncopole Claudius Regaud, Toulouse, France; Groupe Génétique et Cancer, Unicancer, France. Electronic address: guimbaud.r@chu-toulouse.fr.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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