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TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer.

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Title: TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer.
Authors: Abelman RO; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Wu B; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Barnes H; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Medford A; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Norden B; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Putur A; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Bitman E; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Thant W; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Liu T; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Weipert C; Guardant Health, Inc., Palo Alto, California., Fell G; Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Spring LM; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Wander SA; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Moy B; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Vidula N; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Isakoff SJ; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Varkaris A; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Juric D; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Corcoran RB; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ellisen LW; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Ludwig Center at Harvard, Boston, Massachusetts., Bardia A; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 May 15; Vol. 31 (10), pp. 1966-1974.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/1078-0432.CCR-24-2771
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        StartPage: 1966
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              Text: 2025 May 15
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