A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing.
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| Title: | A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing. |
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| Authors: | Ziegler J; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; MongoDB, New York, NY, USA., Hechtman JF; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Caris Life Sciences, Irving, CA, USA., Rana S; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ptashkin RN; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Natera, San Carlos, CA, USA., Jayakumaran G; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Guardant Health, Palo Alto, CA, USA., Middha S; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Adaptimmune, Philadelphia, PA, USA., Chavan SS; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Repertoire Immune Medicines, Cambridge, MA, USA., Vanderbilt C; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., DeLair D; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Northwell Health, Greenvale, NY, USA., Casanova J; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shia J; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., DeGroat N; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Benayed R; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; AstraZeneca, New York, NY, USA., Ladanyi M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Berger MF; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fuchs TJ; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.; Elli Lilly and Company, Indianapolis, IN, USA., Brannon AR; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. brannona@mskcc.org., Zehir A; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Natera, San Carlos, CA, USA. |
| Source: | Nature communications [Nat Commun] 2025 Jan 02; Vol. 16 (1), pp. 136. Date of Electronic Publication: 2025 Jan 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39746944 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Repertoire Immune Medicines, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vanderbilt+C%22">Vanderbilt C</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22DeLair+D%22">DeLair D</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Northwell Health, Greenvale, NY, USA.<br /><searchLink fieldCode="AU" term="%22Casanova+J%22">Casanova J</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shia+J%22">Shia J</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22DeGroat+N%22">DeGroat N</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Benayed+R%22">Benayed R</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; AstraZeneca, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ladanyi+M%22">Ladanyi M</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Berger+MF%22">Berger MF</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fuchs+TJ%22">Fuchs TJ</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.; Elli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Brannon+AR%22">Brannon AR</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. brannona@mskcc.org.<br /><searchLink fieldCode="AU" term="%22Zehir+A%22">Zehir A</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Natera, San Carlos, CA, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Jan 02; Vol. 16 (1), pp. 136. <i>Date of Electronic Publication: </i>2025 Jan 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-024-54970-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 136 Titles: – TitleFull: A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ziegler J – PersonEntity: Name: NameFull: Hechtman JF – PersonEntity: Name: NameFull: Rana S – PersonEntity: Name: NameFull: Ptashkin RN – PersonEntity: Name: NameFull: Jayakumaran G – PersonEntity: Name: NameFull: Middha S – PersonEntity: Name: NameFull: Chavan SS – PersonEntity: Name: NameFull: Vanderbilt C – PersonEntity: Name: NameFull: DeLair D – PersonEntity: Name: NameFull: Casanova J – PersonEntity: Name: NameFull: Shia J – PersonEntity: Name: NameFull: DeGroat N – PersonEntity: Name: NameFull: Benayed R – PersonEntity: Name: NameFull: Ladanyi M – PersonEntity: Name: NameFull: Berger MF – PersonEntity: Name: NameFull: Fuchs TJ – PersonEntity: Name: NameFull: Brannon AR – PersonEntity: Name: NameFull: Zehir A IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 01 Text: 2025 Jan 02 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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