IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2.

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Title: IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2.
Authors: Lee C; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Khan R; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Mantsounga CS; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Sharma S; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Pierce J; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Amelotte E; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Butler CA; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Farinha A; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Parry C; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Caballero O; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Morrison JA; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Uppuluri S; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA., Whyte JJ; Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, Missouri, USA.; Laboratory for Infectious Disease Research, University of Missouri Division of Research, Innovation and Impact, Columbia, Missouri, USA., Kennedy JL; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Arkansas Children's Research Institute, Little Rock, Arkansas, USA., Zhang X; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Choudhary G; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.; Cardiovascular Research Center, Lifespan Cardiovascular Research Institute, Rhode Island Hospital, Providence, Rhode Island, USA., Olson RM; Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, Missouri, USA.; Laboratory for Infectious Disease Research, University of Missouri Division of Research, Innovation and Impact, Columbia, Missouri, USA., Morrison AR; Vascular Research Laboratory, Providence VA Medical Center, Providence, Rhode Island 02908, USA.; Ocean State Research Institute, Inc., Providence, Rhode Island 02908, USA.; Department of Internal Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.; Lead contact and corresponding author.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Feb 13. Date of Electronic Publication: 2025 Feb 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2024.12.24.630260