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Intracerebroventricular anaerobic dopamine in Parkinson's disease with L-dopa-related complications: a phase 1/2 randomized-controlled trial.

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Title: Intracerebroventricular anaerobic dopamine in Parkinson's disease with L-dopa-related complications: a phase 1/2 randomized-controlled trial.
Authors: Moreau C; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France., Odou P; GRITA ULR 7365, University of Lille, Lille, France.; Pharmacy CHU Lille, Lille, France., Labreuche J; Department of Biostatistics, University of Lille, CHU de Lille, Lille, France., Demailly A; InBrain Pharma, Lille, France., Touzet G; Neurosurgery Department, University of Lille, CHU Lille, Lille, France., Reyns N; Neurosurgery Department, University of Lille, CHU Lille, Lille, France., Gouges B; Neurosurgery Department, University of Lille, CHU Lille, Lille, France., Duhamel A; Department of Biostatistics, University of Lille, CHU de Lille, Lille, France., Barthelemy C; Pharmacy CHU Lille, Lille, France., Lannoy D; GRITA ULR 7365, University of Lille, Lille, France.; Pharmacy CHU Lille, Lille, France., Carta N; Pharmacy CHU Lille, Lille, France., Palas B; Pharmacy CHU Lille, Lille, France., Vasseur M; Pharmacy CHU Lille, Lille, France., Marchand F; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France., Ollivier T; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France., Leclercq C; Clinical Studies Pharmacovigilance Department, CHU Lille, Lille, France., Potey C; Clinical Studies Pharmacovigilance Department, CHU Lille, Lille, France., Ouk T; Clinical Studies Pharmacovigilance Department, CHU Lille, Lille, France., Baigne S; InBrain Pharma, Lille, France., Dujardin K; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France., Carton L; Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France., Rolland AS; Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France., Devedjian JC; Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France., Foutel V; InBrain Pharma, Lille, France., Deplanque D; Clinical Studies Pharmacovigilance Department, CHU Lille, Lille, France.; University of Lille, INSERM, CHU Lille, CIC 1403-Centre d'investigation Clinique, Lille, France., Fisichella M; InBrain Pharma, Lille, France., Devos D; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France. david.devos@chru-lille.fr.; Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France. david.devos@chru-lille.fr.
Source: Nature medicine [Nat Med] 2025 Mar; Vol. 31 (3), pp. 819-828. Date of Electronic Publication: 2025 Jan 07.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Clinical Trial, Phase II
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Intracerebroventricular anaerobic dopamine in Parkinson's disease with L-dopa-related complications: a phase 1/2 randomized-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Moreau+C%22">Moreau C</searchLink>; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France.<br /><searchLink fieldCode="AU" term="%22Odou+P%22">Odou P</searchLink>; GRITA ULR 7365, University of Lille, Lille, France.; Pharmacy CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Labreuche+J%22">Labreuche J</searchLink>; Department of Biostatistics, University of Lille, CHU de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Demailly+A%22">Demailly A</searchLink>; InBrain Pharma, Lille, France.<br /><searchLink fieldCode="AU" term="%22Touzet+G%22">Touzet G</searchLink>; Neurosurgery Department, University of Lille, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Reyns+N%22">Reyns N</searchLink>; Neurosurgery Department, University of Lille, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Gouges+B%22">Gouges B</searchLink>; Neurosurgery Department, University of Lille, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Duhamel+A%22">Duhamel A</searchLink>; Department of Biostatistics, University of Lille, CHU de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Barthelemy+C%22">Barthelemy C</searchLink>; Pharmacy CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Lannoy+D%22">Lannoy D</searchLink>; GRITA ULR 7365, University of Lille, Lille, France.; Pharmacy CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Carta+N%22">Carta N</searchLink>; Pharmacy CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Palas+B%22">Palas B</searchLink>; Pharmacy CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Vasseur+M%22">Vasseur M</searchLink>; Pharmacy CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Marchand+F%22">Marchand F</searchLink>; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France.<br /><searchLink fieldCode="AU" term="%22Ollivier+T%22">Ollivier T</searchLink>; 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Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France.<br /><searchLink fieldCode="AU" term="%22Rolland+AS%22">Rolland AS</searchLink>; Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France.<br /><searchLink fieldCode="AU" term="%22Devedjian+JC%22">Devedjian JC</searchLink>; Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France.<br /><searchLink fieldCode="AU" term="%22Foutel+V%22">Foutel V</searchLink>; InBrain Pharma, Lille, France.<br /><searchLink fieldCode="AU" term="%22Deplanque+D%22">Deplanque D</searchLink>; Clinical Studies Pharmacovigilance Department, CHU Lille, Lille, France.; University of Lille, INSERM, CHU Lille, CIC 1403-Centre d'investigation Clinique, Lille, France.<br /><searchLink fieldCode="AU" term="%22Fisichella+M%22">Fisichella M</searchLink>; InBrain Pharma, Lille, France.<br /><searchLink fieldCode="AU" term="%22Devos+D%22">Devos D</searchLink>; Parkinson's Disease Centre of Excellence, Department of Neurology, Univeristy of Lille, CHU Lille, INSERM U1172-Degenerative & Vascular Cognitive Disorders, Lille, France. david.devos@chru-lille.fr.; Department of Medical Pharmacology, University of Lille, INSERM, CHU Lille, U1172-Degenerative & Vascular Cognitive Disorders, LilNCog, Lille Neuroscience & Cognition, LICEND, NS-Park Network, Lille, France. david.devos@chru-lille.fr.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 Mar; Vol. 31 (3), pp. 819-828. <i>Date of Electronic Publication: </i>2025 Jan 07.
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