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Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer.

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Title: Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer.
Authors: Link JM; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA. jmlink@mednet.ucla.edu.; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA. jmlink@mednet.ucla.edu., Eng JR; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Pelz C; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA., MacPherson-Hawthorne K; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Worth PJ; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Surgery, Oregon Health and Science University, Portland, OR, USA., Sivagnanam S; Department of Cell, Development and Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Keith DJ; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA., Owen S; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA., Langer EM; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Center for Early Detection Advanced Research, Oregon Health and Science University, Portland, OR, USA., Grossblatt-Wait A; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Center for Early Detection Advanced Research, Oregon Health and Science University, Portland, OR, USA., Salgado-Garza G; Department of Surgery, Oregon Health and Science University, Portland, OR, USA., Creason AL; Knight Cancer Institute, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Protzek S; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA., Egger J; Knight Cancer Institute, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Holly H; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Heskett MB; Stanford Cancer Institute, Stanford University, Palo Alto, CA, USA., Chin K; Knight Cancer Institute, Portland, OR, USA.; Center for Early Detection Advanced Research, Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Kirchberger N; Department of Cell, Development and Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Betre K; Department of Cell, Development and Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Bucher E; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Kilburn D; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Hu Z; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Munks MW; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA., English IA; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Tsuda M; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Goecks J; Knight Cancer Institute, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Demir E; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Adey AC; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA., Kardosh A; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Hematology and Oncology, Oregon Health and Science University, Portland, OR, USA., Lopez CD; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Hematology and Oncology, Oregon Health and Science University, Portland, OR, USA., Sheppard BC; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Surgery, Oregon Health and Science University, Portland, OR, USA., Guimaraes A; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Radiology, Oregon Health and Science University, Portland, OR, USA., Brinkerhoff B; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, USA., Morgan TK; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Center for Early Detection Advanced Research, Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.; Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, USA., Mills GB; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Oncological Sciences, Oregon Health and Science University, Portland, OR, USA., Coussens LM; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Cell, Development and Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Brody JR; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Portland, OR, USA.; Department of Surgery, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Development and Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Sears RC; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA. searsr@ohsu.edu.; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA. searsr@ohsu.edu.; Knight Cancer Institute, Portland, OR, USA. searsr@ohsu.edu.
Source: Nature cancer [Nat Cancer] 2025 Jan; Vol. 6 (1), pp. 123-144. Date of Electronic Publication: 2025 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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