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Reduced circulating sphingolipids and CERS2 activity are linked to T2D risk and impaired insulin secretion.

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Title: Reduced circulating sphingolipids and CERS2 activity are linked to T2D risk and impaired insulin secretion.
Authors: Khan SR; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; VA Medical Center, Pittsburgh, PA, USA.; Center for Immunometabolism, University of Pittsburgh, Pittsburgh, PA, USA., Ye WW; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Van JAD; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Singh I; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Rabiee Y; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Rodricks KL; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Zhang X; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; VA Medical Center, Pittsburgh, PA, USA.; Center for Immunometabolism, University of Pittsburgh, Pittsburgh, PA, USA., Nicholson RJ; Departments of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA., Razani B; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; VA Medical Center, Pittsburgh, PA, USA.; Center for Immunometabolism, University of Pittsburgh, Pittsburgh, PA, USA., Summers SA; Departments of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA., Futerman AH; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Gunderson EP; Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA., Wheeler MB; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Source: Science advances [Sci Adv] 2025 Jan 10; Vol. 11 (2), pp. eadr1725. Date of Electronic Publication: 2025 Jan 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Khan+SR%22">Khan SR</searchLink>; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; VA Medical Center, Pittsburgh, PA, USA.; Center for Immunometabolism, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ye+WW%22">Ye WW</searchLink>; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Van+JAD%22">Van JAD</searchLink>; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Singh+I%22">Singh I</searchLink>; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rabiee+Y%22">Rabiee Y</searchLink>; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rodricks+KL%22">Rodricks KL</searchLink>; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; VA Medical Center, Pittsburgh, PA, USA.; Center for Immunometabolism, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nicholson+RJ%22">Nicholson RJ</searchLink>; Departments of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Razani+B%22">Razani B</searchLink>; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; VA Medical Center, Pittsburgh, PA, USA.; Center for Immunometabolism, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Summers+SA%22">Summers SA</searchLink>; Departments of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Futerman+AH%22">Futerman AH</searchLink>; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Gunderson+EP%22">Gunderson EP</searchLink>; Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+MB%22">Wheeler MB</searchLink>; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
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