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Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors.

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Bibliographic Details
Title: Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors.
Authors: Sait SF; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Tang KH; Laura and Isaac Perlmutter Cancer Center, Department of Medicine, New York University, New York, NY 10016.; Translational Medicine, AstraZeneca, Waltham, MA 02451., Angus SP; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Brown R; Medicine, Hematology and Medical Oncology, Neurosurgery, The Mount Sinai Hospital, New York, NY 10029., Sun D; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Department of Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin, Milwaukee, WI 53226.; Cancer Center, The Medical College of Wisconsin, Milwaukee, WI 53226., Xie X; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065., Iltis C; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065., Lien M; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065., D Socci N; Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Bale TA; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Davis C; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Dixon SAH; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Zhang C; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Wade Clapp D; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Neel BG; Laura and Isaac Perlmutter Cancer Center, Department of Medicine, New York University, New York, NY 10016., Parada LF; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurology, Memorial Sloan Kettering Cancer Center, NY 10065.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jan 07; Vol. 122 (1), pp. e2407745121. Date of Electronic Publication: 2024 Dec 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2407745121