Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors.
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| Title: | Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors. |
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| Authors: | Sait SF; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Tang KH; Laura and Isaac Perlmutter Cancer Center, Department of Medicine, New York University, New York, NY 10016.; Translational Medicine, AstraZeneca, Waltham, MA 02451., Angus SP; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Brown R; Medicine, Hematology and Medical Oncology, Neurosurgery, The Mount Sinai Hospital, New York, NY 10029., Sun D; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Department of Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin, Milwaukee, WI 53226.; Cancer Center, The Medical College of Wisconsin, Milwaukee, WI 53226., Xie X; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065., Iltis C; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065., Lien M; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065., D Socci N; Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Bale TA; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Davis C; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Dixon SAH; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Zhang C; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Wade Clapp D; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202., Neel BG; Laura and Isaac Perlmutter Cancer Center, Department of Medicine, New York University, New York, NY 10016., Parada LF; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurology, Memorial Sloan Kettering Cancer Center, NY 10065. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jan 07; Vol. 122 (1), pp. e2407745121. Date of Electronic Publication: 2024 Dec 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39793045 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sait+SF%22">Sait SF</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Tang+KH%22">Tang KH</searchLink>; Laura and Isaac Perlmutter Cancer Center, Department of Medicine, New York University, New York, NY 10016.; Translational Medicine, AstraZeneca, Waltham, MA 02451.<br /><searchLink fieldCode="AU" term="%22Angus+SP%22">Angus SP</searchLink>; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202.<br /><searchLink fieldCode="AU" term="%22Brown+R%22">Brown R</searchLink>; Medicine, Hematology and Medical Oncology, Neurosurgery, The Mount Sinai Hospital, New York, NY 10029.<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Department of Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin, Milwaukee, WI 53226.; Cancer Center, The Medical College of Wisconsin, Milwaukee, WI 53226.<br /><searchLink fieldCode="AU" term="%22Xie+X%22">Xie X</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Iltis+C%22">Iltis C</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Lien+M%22">Lien M</searchLink>; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22D+Socci+N%22">D Socci N</searchLink>; Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Bale+TA%22">Bale TA</searchLink>; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Davis+C%22">Davis C</searchLink>; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202.<br /><searchLink fieldCode="AU" term="%22Dixon+SAH%22">Dixon SAH</searchLink>; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202.<br /><searchLink fieldCode="AU" term="%22Wade+Clapp+D%22">Wade Clapp D</searchLink>; Indiana University School of Medicine, Department of Pediatrics, Riley Hospital for Children at IU Health, Indianapolis, IN 46202.<br /><searchLink fieldCode="AU" term="%22Neel+BG%22">Neel BG</searchLink>; Laura and Isaac Perlmutter Cancer Center, Department of Medicine, New York University, New York, NY 10016.<br /><searchLink fieldCode="AU" term="%22Parada+LF%22">Parada LF</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, New York, NY 10065.; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurology, Memorial Sloan Kettering Cancer Center, NY 10065. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Jan 07; Vol. 122 (1), pp. e2407745121. <i>Date of Electronic Publication: </i>2024 Dec 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39793045 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2407745121 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e2407745121 Titles: – TitleFull: Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sait SF – PersonEntity: Name: NameFull: Tang KH – PersonEntity: Name: NameFull: Angus SP – PersonEntity: Name: NameFull: Brown R – PersonEntity: Name: NameFull: Sun D – PersonEntity: Name: NameFull: Xie X – PersonEntity: Name: NameFull: Iltis C – PersonEntity: Name: NameFull: Lien M – PersonEntity: Name: NameFull: D Socci N – PersonEntity: Name: NameFull: Bale TA – PersonEntity: Name: NameFull: Davis C – PersonEntity: Name: NameFull: Dixon SAH – PersonEntity: Name: NameFull: Zhang C – PersonEntity: Name: NameFull: Wade Clapp D – PersonEntity: Name: NameFull: Neel BG – PersonEntity: Name: NameFull: Parada LF IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 01 Text: 2025 Jan 07 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1091-6490 Numbering: – Type: volume Value: 122 – Type: issue Value: 1 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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