A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity.

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Title: A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity.
Authors: Smith AA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Su H; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.; Center for Veterinary Science, Zhejiang University, Hangzhou, China., Wallach J; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Liu Y; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Maiello P; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Borish HJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Winchell C; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Simonson AW; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lin PL; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rodgers M; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Fillmore D; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sakal J; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lin K; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Vinette V; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. dis2003@med.cornell.edu., Ehrt S; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. sae2004@med.cornell.edu., Flynn JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. joanne@pitt.edu.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. joanne@pitt.edu.
Source: Nature microbiology [Nat Microbiol] 2025 Feb; Vol. 10 (2), pp. 468-481. Date of Electronic Publication: 2025 Jan 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
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  Data: A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity.
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  Data: <searchLink fieldCode="AU" term="%22Smith+AA%22">Smith AA</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Su+H%22">Su H</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.; Center for Veterinary Science, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wallach+J%22">Wallach J</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Maiello+P%22">Maiello P</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Borish+HJ%22">Borish HJ</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Winchell+C%22">Winchell C</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Simonson+AW%22">Simonson AW</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+PL%22">Lin PL</searchLink>; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rodgers+M%22">Rodgers M</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fillmore+D%22">Fillmore D</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sakal+J%22">Sakal J</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vinette+V%22">Vinette V</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schnappinger+D%22">Schnappinger D</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. dis2003@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Ehrt+S%22">Ehrt S</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. sae2004@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Flynn+JL%22">Flynn JL</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. joanne@pitt.edu.; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. joanne@pitt.edu.
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  Data: <searchLink fieldCode="JN" term="%22101674869%22">Nature microbiology</searchLink> [Nat Microbiol] 2025 Feb; Vol. 10 (2), pp. 468-481. <i>Date of Electronic Publication: </i>2025 Jan 10.
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