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Sophaline B inhibits non-small cell lung cancer by activating NLRP3/caspase-1/GSDMD-dependent pyroptosis and PI3K/AKT/mTOR-mediated autophagy.

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Title: Sophaline B inhibits non-small cell lung cancer by activating NLRP3/caspase-1/GSDMD-dependent pyroptosis and PI3K/AKT/mTOR-mediated autophagy.
Authors: Hou Y; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China., Wang Z; Department of Interventional, Shenzhen People's Hospital, Shenzhen, Guangdong, China., Wu Y; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China., Deng T; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China., Yang S; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China., Ma S; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China., Zhang Y; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China., Luo D; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China., Chen Y; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China., Dai X; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.
Source: Natural product research [Nat Prod Res] 2026 Jun; Vol. 40 (11), pp. 3015-3027. Date of Electronic Publication: 2025 Jan 11.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sophaline B inhibits non-small cell lung cancer by activating NLRP3/caspase-1/GSDMD-dependent pyroptosis and PI3K/AKT/mTOR-mediated autophagy.
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  Data: <searchLink fieldCode="AU" term="%22Hou+Y%22">Hou Y</searchLink>; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Interventional, Shenzhen People's Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Deng+T%22">Deng T</searchLink>; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Ma+S%22">Ma S</searchLink>; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Luo+D%22">Luo D</searchLink>; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Subject Service and Consultation, Jinan University Library, Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Dai+X%22">Dai X</searchLink>; Institute of Biopharmaceutical and Health Engineering, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Gene and Antibody Therapy, Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong, China.
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  Data: <searchLink fieldCode="JN" term="%22101167924%22">Natural product research</searchLink> [Nat Prod Res] 2026 Jun; Vol. 40 (11), pp. 3015-3027. <i>Date of Electronic Publication: </i>2025 Jan 11.
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              Text: 2026 Jun
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