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Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials.

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Title: Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials.
Authors: Venkatraman N; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Tiono AB; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Bowyer G; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Bellamy DG; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Stockdale LK; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Powlson J; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Collins KA; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Coulibaly S; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Datoo MS; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Silman D; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Ouedraogo A; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Nébié I; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Imoukhuede EB; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Brod F; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Folegatti P; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Dickinson-Craig E; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Jamieson S; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Bougouma EC; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Wright D; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Diarra A; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Bliss CM; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Morter R; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Glenn G; Novavax, Gaithersburg, MD, USA., Fries LF; Novavax, Gaithersburg, MD, USA., Reimer JM; Novavax, Uppsala, Sweden., Lövgren-Bengtsson K; Novavax, Uppsala, Sweden., Baker M; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Poulton I; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Moyle S; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Berrie E; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Green N; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Mukhopadhyay E; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Viebig NK; European Vaccine Initiative, Universitäts Klinikum Heidelberg, Heidelberg, Germany., Angus B; Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Lawrie A; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Roberts R; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Gilbert SC; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Lewis DJM; NIHR Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, London, UK., Sirima SB; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso; Groupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso., Ewer KJ; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: katie.j.ewer@gsk.com., Hill AVS; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk.
Source: The Lancet. Microbe [Lancet Microbe] 2025 Mar; Vol. 6 (3), pp. 100868. Date of Electronic Publication: 2025 Jan 10.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials.
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  Data: <searchLink fieldCode="AU" term="%22Venkatraman+N%22">Venkatraman N</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tiono+AB%22">Tiono AB</searchLink>; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Bowyer+G%22">Bowyer G</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bellamy+DG%22">Bellamy DG</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Stockdale+LK%22">Stockdale LK</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Powlson+J%22">Powlson J</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Collins+KA%22">Collins KA</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Coulibaly+S%22">Coulibaly S</searchLink>; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Datoo+MS%22">Datoo MS</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Silman+D%22">Silman D</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ouedraogo+A%22">Ouedraogo A</searchLink>; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Nébié+I%22">Nébié I</searchLink>; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Imoukhuede+EB%22">Imoukhuede EB</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Brod+F%22">Brod F</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Folegatti+P%22">Folegatti P</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dickinson-Craig+E%22">Dickinson-Craig E</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jamieson+S%22">Jamieson S</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bougouma+EC%22">Bougouma EC</searchLink>; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Wright+D%22">Wright D</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Diarra+A%22">Diarra A</searchLink>; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Bliss+CM%22">Bliss CM</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Morter+R%22">Morter R</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Glenn+G%22">Glenn G</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fries+LF%22">Fries LF</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Reimer+JM%22">Reimer JM</searchLink>; Novavax, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Lövgren-Bengtsson+K%22">Lövgren-Bengtsson K</searchLink>; Novavax, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Baker+M%22">Baker M</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Poulton+I%22">Poulton I</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Moyle+S%22">Moyle S</searchLink>; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Berrie+E%22">Berrie E</searchLink>; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Green+N%22">Green N</searchLink>; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mukhopadhyay+E%22">Mukhopadhyay E</searchLink>; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Viebig+NK%22">Viebig NK</searchLink>; European Vaccine Initiative, Universitäts Klinikum Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Angus+B%22">Angus B</searchLink>; Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lawrie+A%22">Lawrie A</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gilbert+SC%22">Gilbert SC</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lewis+DJM%22">Lewis DJM</searchLink>; NIHR Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Sirima+SB%22">Sirima SB</searchLink>; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso; Groupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: katie.j.ewer@gsk.com.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk.
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