Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials.
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| Title: | Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials. |
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| Authors: | Venkatraman N; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Tiono AB; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Bowyer G; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Bellamy DG; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Stockdale LK; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Powlson J; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Collins KA; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Coulibaly S; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Datoo MS; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Silman D; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Ouedraogo A; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Nébié I; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Imoukhuede EB; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Brod F; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Folegatti P; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Dickinson-Craig E; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Jamieson S; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Bougouma EC; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Wright D; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Diarra A; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso., Bliss CM; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Morter R; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Glenn G; Novavax, Gaithersburg, MD, USA., Fries LF; Novavax, Gaithersburg, MD, USA., Reimer JM; Novavax, Uppsala, Sweden., Lövgren-Bengtsson K; Novavax, Uppsala, Sweden., Baker M; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Poulton I; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Moyle S; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Berrie E; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Green N; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Mukhopadhyay E; Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford, UK., Viebig NK; European Vaccine Initiative, Universitäts Klinikum Heidelberg, Heidelberg, Germany., Angus B; Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Lawrie A; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Roberts R; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Gilbert SC; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK., Lewis DJM; NIHR Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, London, UK., Sirima SB; Centre National de Recherche et Formation sur le Paludisme (CNRFP) Research Unit, Banfora, Burkina Faso; Groupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso., Ewer KJ; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: katie.j.ewer@gsk.com., Hill AVS; Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk. |
| Source: | The Lancet. Microbe [Lancet Microbe] 2025 Mar; Vol. 6 (3), pp. 100868. Date of Electronic Publication: 2025 Jan 10. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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