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Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.

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Title: Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.
Authors: Black JRM; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK., Bartha G; Personalis Inc., Fremont, CA, USA., Abbott CW; Personalis Inc., Fremont, CA, USA., Boyle SM; Personalis Inc., Fremont, CA, USA., Karasaki T; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK.; Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK.; Department of Thoracic Surgery, Respiratory Center, Toranomon Hospital, Tokyo, Japan., Li B; Personalis Inc., Fremont, CA, USA., Chen R; Personalis Inc., Fremont, CA, USA., Harris J; Personalis Inc., Fremont, CA, USA., Veeriah S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Colopi M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Bakir MA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK., Liu WK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Lyle J; Personalis Inc., Fremont, CA, USA., Navarro FCP; Personalis Inc., Fremont, CA, USA., Northcott J; Personalis Inc., Fremont, CA, USA., Pyke RM; Personalis Inc., Fremont, CA, USA., Hill MS; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK., Thol K; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Huebner A; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Bailey C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK., Colliver EC; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK., Martínez-Ruiz C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Grigoriadis K; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Pawlik P; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Marinelli D; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Experimental Medicine, Sapienza University, Rome, Italy., Shutkever OG; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Murphy C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK., Sivakumar M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Shaw JA; Leicester NIHR BRC & University of Leicester, Leicester, UK., Hackshaw A; Cancer Research UK & UCL Cancer Trials Centre, London, UK., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK.; Department of Oncology, University College London Hospitals, London, UK., Frankell AM; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK., Chen RO; Personalis Inc., Fremont, CA, USA., Swanton C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. Charles.swanton@crick.ac.uk.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK. Charles.swanton@crick.ac.uk.; Department of Oncology, University College London Hospitals, London, UK. Charles.swanton@crick.ac.uk.
Corporate Authors: TRACERx consortium
Source: Nature medicine [Nat Med] 2025 Jan; Vol. 31 (1), pp. 70-76. Date of Electronic Publication: 2025 Jan 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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  Data: Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.
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Charles.swanton@crick.ac.uk.; Cancer Evolution and Genome Instability Laboratory., The Francis Crick Institute, London, UK. Charles.swanton@crick.ac.uk.; Department of Oncology, University College London Hospitals, London, UK. Charles.swanton@crick.ac.uk.
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