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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity.

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Title: A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity.
Authors: Zhang DY; Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China.; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Zhang ZH; Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Liu WT; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Zhou WM; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Zhou PF; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Wei JJ; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Dai XJ; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Zeng XL; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Zhou YQ; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Li HW; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Zhang H; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China., Shen AL; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. shenaolin@ustc.edu.cn.; Department of General Surgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, Anhui, China. shenaolin@ustc.edu.cn., Cheng LS; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China. charlson@ustc.edu.cn.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. charlson@ustc.edu.cn., Shen GD; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn.; Department of Geriatrics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn., He YF; Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China. yifuhe@ffyy.ustc.edu.cn.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. yifuhe@ffyy.ustc.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2025 Jan 13; Vol. 23 (1), pp. 53. Date of Electronic Publication: 2025 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+DY%22">Zhang DY</searchLink>; Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China.; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZH%22">Zhang ZH</searchLink>; Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Liu+WT%22">Liu WT</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhou+WM%22">Zhou WM</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhou+PF%22">Zhou PF</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Wei+JJ%22">Wei JJ</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Dai+XJ%22">Dai XJ</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zeng+XL%22">Zeng XL</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhou+YQ%22">Zhou YQ</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Li+HW%22">Li HW</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Shen+AL%22">Shen AL</searchLink>; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. shenaolin@ustc.edu.cn.; Department of General Surgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, Anhui, China. shenaolin@ustc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Cheng+LS%22">Cheng LS</searchLink>; Hefei HankeMab Biotechnology Co., Ltd.; Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei, Anhui Anke Biotechnology (Group) Co., Ltd, Hefei, 230031, Anhui, China. charlson@ustc.edu.cn.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. charlson@ustc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shen+GD%22">Shen GD</searchLink>; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn.; Department of Geriatrics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, Anhui, China. gdshen@ustc.edu.cn.<br /><searchLink fieldCode="AU" term="%22He+YF%22">He YF</searchLink>; Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China. yifuhe@ffyy.ustc.edu.cn.; Anhui Province Key Laboratory of Geriatric Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province, Hefei, 230001, Anhui, China. yifuhe@ffyy.ustc.edu.cn.
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        Value: 10.1186/s12967-025-06107-z
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