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Design, Synthesis, and Pharmacological Evaluation of Nonsteroidal Tricyclic Ligands as Modulators of GABAA Receptors.

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Title: Design, Synthesis, and Pharmacological Evaluation of Nonsteroidal Tricyclic Ligands as Modulators of GABAA Receptors.
Authors: Xu Y; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Mortensen M; Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K., Liebowitz S; Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K., Jensen NN; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark., Tian Y; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark., Bavo F; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark., Seidel T; Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, University of Vienna, Vienna 1090, Austria., Smart TG; Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K., Frølund B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Feb 13; Vol. 68 (3), pp. 3795-3813. Date of Electronic Publication: 2025 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, Synthesis, and Pharmacological Evaluation of Nonsteroidal Tricyclic Ligands as Modulators of GABA<subscript>A</subscript> Receptors.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Mortensen+M%22">Mortensen M</searchLink>; Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K.<br /><searchLink fieldCode="AU" term="%22Liebowitz+S%22">Liebowitz S</searchLink>; Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K.<br /><searchLink fieldCode="AU" term="%22Jensen+NN%22">Jensen NN</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.<br /><searchLink fieldCode="AU" term="%22Bavo+F%22">Bavo F</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.<br /><searchLink fieldCode="AU" term="%22Seidel+T%22">Seidel T</searchLink>; Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, University of Vienna, Vienna 1090, Austria.<br /><searchLink fieldCode="AU" term="%22Smart+TG%22">Smart TG</searchLink>; Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K.<br /><searchLink fieldCode="AU" term="%22Frølund+B%22">Frølund B</searchLink>; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Feb 13; Vol. 68 (3), pp. 3795-3813. <i>Date of Electronic Publication: </i>2025 Jan 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.4c02881
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              Text: 2025 Feb 13
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