Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.
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| Title: | Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning. |
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| Authors: | Luo J; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Deep Piction, Munich, Germany., Molbay M; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Medical Research School (MMRS), Munich, Germany.; Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, Ludwig-Maximilians-University Munich, Munich, Germany., Chen Y; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Munich Medical Research School (MMRS), Munich, Germany.; Faculty of Medicine, Ludwig-Maximilians University Munich, Munich, Germany., Horvath I; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Deep Piction, Munich, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Munich, Germany., Kadletz K; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Deep Piction, Munich, Germany., Kick B; Department of Biosciences, School of Natural Sciences, Technical University of Munich, Garching, Germany.; Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany., Zhao S; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Medical Research School (MMRS), Munich, Germany.; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.; ETH Zurich, Institute for Molecular Health Sciences, Zurich, Switzerland., Al-Maskari R; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Deep Piction, Munich, Germany.; TUM School of Computation, Information and Technology, Technical University of Munich, Munich, Germany., Singh I; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Medicine, Technische Universität München, Munich, Germany., Ali M; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Graduate School of Neuroscience (GSN), Munich, Germany.; Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany., Bhatia HS; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Deep Piction, Munich, Germany., Minde DP; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany., Negwer M; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Deep Piction, Munich, Germany., Hoeher L; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany., Calandra GM; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Groschup B; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Su J; Institute of Virology, Technical University of Munich / Helmholtz Munich, Munich, Germany.; German Center for Infection Research (DZIF), Munich partner site, Munich, Germany., Kimna C; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Deep Piction, Munich, Germany., Rong Z; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Munich Medical Research School (MMRS), Munich, Germany., Galensowske N; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany., Todorov MI; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Deep Piction, Munich, Germany., Jeridi D; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Deep Piction, Munich, Germany., Ohn TL; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany., Roth S; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany., Simats A; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany., Singh V; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Khalin I; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), GIP Cyceron, Institute Blood and Brain @Caen-Normandie (BB@C), Caen, France., Pan C; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany., Arús BA; Department of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Helmholtz Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany., Bruns OT; Department of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Helmholtz Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Helmholtz Pioneer Campus, Helmholtz Zentrum München, Neuherberg, Germany., Zeidler R; Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Structural Biology, Munich, Germany.; Department of Otorhinolaryngology, LMU University Hospital, LMU Munich, Munich, Germany., Liesz A; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Protzer U; Institute of Virology, Technical University of Munich / Helmholtz Munich, Munich, Germany.; German Center for Infection Research (DZIF), Munich partner site, Munich, Germany., Plesnila N; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Ussar S; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hellal F; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Paetzold J; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Deep Piction, Munich, Germany.; Department of Computing, Imperial College London, London, UK., Elsner M; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.; Deep Piction, Munich, Germany., Dietz H; Department of Biosciences, School of Natural Sciences, Technical University of Munich, Garching, Germany. dietz@tum.de.; Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany. dietz@tum.de., Erturk A; Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany. ali.erturk@helmholtz-munich.de.; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany. ali.erturk@helmholtz-munich.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ali.erturk@helmholtz-munich.de.; Deep Piction, Munich, Germany. ali.erturk@helmholtz-munich.de.; School of Medicine, Koç University, İstanbul, Turkey. ali.erturk@helmholtz-munich.de. |
| Source: | Nature biotechnology [Nat Biotechnol] 2025 Dec; Vol. 43 (12), pp. 2009-2022. Date of Electronic Publication: 2025 Jan 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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