CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial.
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| Title: | CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial. |
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| Authors: | Montagne JM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mitchell JT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore MD, USA., Tandurella JA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Christenson ES; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Danilova LV; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Deshpande A; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Loth M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sidiropoulos DN; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Davis-Marcisak E; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore MD, USA., Bergman DR; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhu Q; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wang H; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kagohara LT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Engle LL; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Green BF; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Favorov AV; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Laboratory of Systems Biology and Computational Genetics, Vavilov Institute of General Genetics, Moscow, RF, Russia., Ho WJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lim SJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhang R; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Li P; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gai J; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mo G; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mitchell S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wang R; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Vaghasia A; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hou W; Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA., Xu Y; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zimmerman JW; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Elisseeff JH; Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yegnasubramanian S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; InHealth Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Pancreatic Cancer Precision Medicine Center of Excellence Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Anders RA; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Jaffee EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Pancreatic Cancer Precision Medicine Center of Excellence Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zheng L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Pancreatic Cancer Precision Medicine Center of Excellence Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Fertig EJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Skip Viragh Center for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Applied Mathematics and Statistics, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA. |
| Source: | IScience [iScience] 2024 Dec 10; Vol. 28 (1), pp. 111569. Date of Electronic Publication: 2024 Dec 10 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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