Hypomorphic RAG2 Deficiency Promotes Selection of Self-Reactive B Cells.

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Title: Hypomorphic RAG2 Deficiency Promotes Selection of Self-Reactive B Cells.
Authors: Thouvenel CD; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA., Tipton CM; Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, USA., Yamazaki Y; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Zhang TT; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA., Rylaarsdam S; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA., Hom JR; Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, USA., Snead C; Immunome Inc, Bothell, WA, USA., Zhu C; Department of Immunology, Microarray and Immune Phenotyping Core, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li QZ; Genecopia Inc, Rockville, MD, USA., Lee YN; Pediatric Department A and the Immunology Service, Ramat-Gan and Sackler Faculty of Medicine, 'Edmond and Lily Safra' Children's Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel., Kawai T; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Haque N; Bioinformatics Research and Development Laboratory, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Zimmermann MT; Bioinformatics Research and Development Laboratory, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Ponnan SM; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA., Jackson SW; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., James RG; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA., Sanz I; Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, USA., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Torgerson TR; Allen Institute for Immunology, Seattle, WA, USA., Ochs HD; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., Rawlings DJ; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA. drawlings@uw.edu.; Department of Pediatrics, University of Washington, Seattle, WA, USA. drawlings@uw.edu.; Department of Immunology, University of Washington, Seattle, WA, USA. drawlings@uw.edu., Allenspach EJ; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA. eric.allenspach@seattlechildrens.org.; Department of Pediatrics, University of Washington, Seattle, WA, USA. eric.allenspach@seattlechildrens.org.
Source: Journal of clinical immunology [J Clin Immunol] 2025 Jan 15; Vol. 45 (1), pp. 66. Date of Electronic Publication: 2025 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8102137 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2592 (Electronic) Linking ISSN: 02719142 NLM ISO Abbreviation: J Clin Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-2592
DOI:10.1007/s10875-024-01849-9