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Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution.

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Title: Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution.
Authors: Espejo Valle-Inclan J; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK., De Noon S; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK., Trevers K; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK., Elrick H; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK., van Belzen IAEM; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK., Zumalave S; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK., Sauer CM; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK., Tanguy M; Scientific Research and Development, Genomics England, One Canada Square, London E14 5AB, UK., Butters T; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK., Muyas F; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK., Rust AG; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK., Amary F; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK., Tirabosco R; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK., Giess A; Scientific Research and Development, Genomics England, One Canada Square, London E14 5AB, UK., Sosinsky A; Genomics England, One Canada Square, London E14 5AB, UK., Elgar G; Scientific Research and Development, Genomics England, One Canada Square, London E14 5AB, UK., Flanagan AM; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK. Electronic address: a.flanagan@ucl.ac.uk., Cortés-Ciriano I; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK. Electronic address: icortes@ebi.ac.uk.
Source: Cell [Cell] 2025 Jan 23; Vol. 188 (2), pp. 352-370.e22. Date of Electronic Publication: 2025 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Espejo+Valle-Inclan+J%22">Espejo Valle-Inclan J</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22De+Noon+S%22">De Noon S</searchLink>; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK.<br /><searchLink fieldCode="AU" term="%22Trevers+K%22">Trevers K</searchLink>; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK.<br /><searchLink fieldCode="AU" term="%22Elrick+H%22">Elrick H</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22van+Belzen+IAEM%22">van Belzen IAEM</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Zumalave+S%22">Zumalave S</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Sauer+CM%22">Sauer CM</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Tanguy+M%22">Tanguy M</searchLink>; Scientific Research and Development, Genomics England, One Canada Square, London E14 5AB, UK.<br /><searchLink fieldCode="AU" term="%22Butters+T%22">Butters T</searchLink>; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK.<br /><searchLink fieldCode="AU" term="%22Muyas+F%22">Muyas F</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Rust+AG%22">Rust AG</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Amary+F%22">Amary F</searchLink>; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK.<br /><searchLink fieldCode="AU" term="%22Tirabosco+R%22">Tirabosco R</searchLink>; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK.<br /><searchLink fieldCode="AU" term="%22Giess+A%22">Giess A</searchLink>; Scientific Research and Development, Genomics England, One Canada Square, London E14 5AB, UK.<br /><searchLink fieldCode="AU" term="%22Sosinsky+A%22">Sosinsky A</searchLink>; Genomics England, One Canada Square, London E14 5AB, UK.<br /><searchLink fieldCode="AU" term="%22Elgar+G%22">Elgar G</searchLink>; Scientific Research and Development, Genomics England, One Canada Square, London E14 5AB, UK.<br /><searchLink fieldCode="AU" term="%22Flanagan+AM%22">Flanagan AM</searchLink>; Research Department of Pathology, University College London Cancer Institute, London WC1E 6DD, UK; Department of Histopathology, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK. Electronic address: a.flanagan@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Cortés-Ciriano+I%22">Cortés-Ciriano I</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton CB10 1SA, UK. Electronic address: icortes@ebi.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2025 Jan 23; Vol. 188 (2), pp. 352-370.e22. <i>Date of Electronic Publication: </i>2025 Jan 14.
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