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JAK2 is a critical therapeutic target in VEXAS syndrome treated with ruxolitinib.

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Title: JAK2 is a critical therapeutic target in VEXAS syndrome treated with ruxolitinib.
Authors: Ceccardi A; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy., Dameri M; IRCCS Policlinico San Martino, Genoa, Italy., Ravera F; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy., Gilardi N; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy., Stabile M; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.; Institut Jules Bordet, Bruxelles, Belgium., Lombardo I; Beyond Pharma Ltd., Milan, Italy., Ceresa D; IRCCS Policlinico San Martino, Genoa, Italy., Colombo M; Molecular Pathology Unit, IRCCS Policlinico San Martino, Genoa, Italy., Vigo T; Laboratory of Experimental Neuroscience, IRCCS Policlinico San Martino, Genoa, Italy., Cigolini B; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy., Rivoli G; Hematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Dragani M; Hematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Solimano I; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy., Garuti A; IRCCS Policlinico San Martino, Genoa, Italy., Bellodi A; IRCCS Policlinico San Martino, Genoa, Italy., Ballestrero A; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy., Ferrando L; IRCCS Policlinico San Martino, Genoa, Italy., Zoppoli G; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.
Source: British journal of haematology [Br J Haematol] 2025 Feb; Vol. 206 (2), pp. 758-762. Date of Electronic Publication: 2025 Jan 15.
Publication Type: Letter
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: JAK2 is a critical therapeutic target in VEXAS syndrome treated with ruxolitinib.
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  Data: <searchLink fieldCode="AU" term="%22Ceccardi+A%22">Ceccardi A</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Dameri+M%22">Dameri M</searchLink>; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ravera+F%22">Ravera F</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Gilardi+N%22">Gilardi N</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Stabile+M%22">Stabile M</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.; Institut Jules Bordet, Bruxelles, Belgium.<br /><searchLink fieldCode="AU" term="%22Lombardo+I%22">Lombardo I</searchLink>; Beyond Pharma Ltd., Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ceresa+D%22">Ceresa D</searchLink>; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+M%22">Colombo M</searchLink>; Molecular Pathology Unit, IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Vigo+T%22">Vigo T</searchLink>; Laboratory of Experimental Neuroscience, IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Cigolini+B%22">Cigolini B</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Rivoli+G%22">Rivoli G</searchLink>; Hematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Dragani+M%22">Dragani M</searchLink>; Hematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Solimano+I%22">Solimano I</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Garuti+A%22">Garuti A</searchLink>; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Bellodi+A%22">Bellodi A</searchLink>; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ballestrero+A%22">Ballestrero A</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrando+L%22">Ferrando L</searchLink>; IRCCS Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Zoppoli+G%22">Zoppoli G</searchLink>; Department of Internal Medicine and Medical Specialties (DiMI), Università di Genova, Genoa, Italy.; IRCCS Policlinico San Martino, Genoa, Italy.
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  Data: <searchLink fieldCode="JN" term="%220372544%22">British journal of haematology</searchLink> [Br J Haematol] 2025 Feb; Vol. 206 (2), pp. 758-762. <i>Date of Electronic Publication: </i>2025 Jan 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0372544 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2141 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200071048%22">00071048 </searchLink><i>NLM ISO Abbreviation: </i>Br J Haematol <i>Subsets: </i>MEDLINE; In Process
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