De novo designed proteins neutralize lethal snake venom toxins.
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| Title: | De novo designed proteins neutralize lethal snake venom toxins. |
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| Authors: | Vázquez Torres S; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA., Benard Valle M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Mackessy SP; Department of Biological Sciences, University of Northern Colorado, Greeley, CO, USA., Menzies SK; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.; Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.; Biomedical & Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK., Casewell NR; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.; Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Ahmadi S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Burlet NJ; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Muratspahić E; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Sappington I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA., Overath MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Ledergerber J; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Boddum K; Sophion Bioscience, Ballerup, Denmark., Bera AK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Kang A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Brackenbrough E; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Cardoso IA; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Crittenden EP; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Edge RJ; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Decarreau J; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Ragotte RJ; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Pillai AS; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Abedi M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Han HL; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Gerben SR; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Murray A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Skotheim R; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Stuart L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Stewart L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Fryer TJA; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Jenkins TP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. tpaje@dtu.dk., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu. |
| Source: | Nature [Nature] 2025 Mar; Vol. 639 (8053), pp. 225-231. Date of Electronic Publication: 2025 Jan 15. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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