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Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.

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Title: Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.
Authors: Geurs S; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium., Staessens E; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Bredael K; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., Borghgraef S; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., De Ridder J; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., Persoons L; Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium., De Jonghe S; Molecular Structural and Translational Virology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium., Schols D; Molecular Structural and Translational Virology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium., Mann MK; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada., Franceus J; Center for Synthetic Biology, Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., Desmet T; Center for Synthetic Biology, Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., Van Hecke K; XStruct, Department of Chemistry, Faculty of Sciences, Ghent University, Ghent, Belgium., Clarisse D; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address: dorien.clarisse@vib-ugent.be., De Bosscher K; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address: karolien.debosscher@vib-ugent.be., D'hooghe M; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address: matthias.dhooghe@ugent.be.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Mar 05; Vol. 285, pp. 117208. Date of Electronic Publication: 2024 Dec 27.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.
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  Data: <searchLink fieldCode="AU" term="%22Geurs+S%22">Geurs S</searchLink>; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Staessens+E%22">Staessens E</searchLink>; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Bredael+K%22">Bredael K</searchLink>; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Borghgraef+S%22">Borghgraef S</searchLink>; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Ridder+J%22">De Ridder J</searchLink>; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Persoons+L%22">Persoons L</searchLink>; Molecular Genetics and Therapeutics in Virology and Oncology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Jonghe+S%22">De Jonghe S</searchLink>; Molecular Structural and Translational Virology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Schols+D%22">Schols D</searchLink>; Molecular Structural and Translational Virology Research Group, Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Mann+MK%22">Mann MK</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Harding+RJ%22">Harding RJ</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Franceus+J%22">Franceus J</searchLink>; Center for Synthetic Biology, Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Desmet+T%22">Desmet T</searchLink>; Center for Synthetic Biology, Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Hecke+K%22">Van Hecke K</searchLink>; XStruct, Department of Chemistry, Faculty of Sciences, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Clarisse+D%22">Clarisse D</searchLink>; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address: dorien.clarisse@vib-ugent.be.<br /><searchLink fieldCode="AU" term="%22De+Bosscher+K%22">De Bosscher K</searchLink>; Translational Nuclear Receptor Research, VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address: karolien.debosscher@vib-ugent.be.<br /><searchLink fieldCode="AU" term="%22D'hooghe+M%22">D'hooghe M</searchLink>; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address: matthias.dhooghe@ugent.be.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2025 Mar 05; Vol. 285, pp. 117208. <i>Date of Electronic Publication: </i>2024 Dec 27.
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