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First generation vanadium-based PTEN inhibitors: Comparative study in vitro and in vivo and identification of a novel mechanism of action.

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Title: First generation vanadium-based PTEN inhibitors: Comparative study in vitro and in vivo and identification of a novel mechanism of action.
Authors: Premeti K; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Tsipa D; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Nadalis AE; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Papanikolaou MG; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece; Department of Chemistry, University of Cyprus, Nicosia 2109, Cyprus., Syropoulou V; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Karagkiozeli KD; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Aggelis G; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Iordanidou E; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece., Labrakakis C; Department of Biological Applications and Technology, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece., Pappas P; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Keramidas AD; Department of Chemistry, University of Cyprus, Nicosia 2109, Cyprus., Antoniou K; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece., Doulias PT; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece., Kabanos TA; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece., Leondaritis G; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece. Electronic address: gleondar@uoi.gr.
Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Mar; Vol. 233, pp. 116756. Date of Electronic Publication: 2025 Jan 15.
Publication Type: Journal Article; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Premeti+K%22">Premeti K</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Tsipa+D%22">Tsipa D</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Nadalis+AE%22">Nadalis AE</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Papanikolaou+MG%22">Papanikolaou MG</searchLink>; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece; Department of Chemistry, University of Cyprus, Nicosia 2109, Cyprus.<br /><searchLink fieldCode="AU" term="%22Syropoulou+V%22">Syropoulou V</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Karagkiozeli+KD%22">Karagkiozeli KD</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Aggelis+G%22">Aggelis G</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Iordanidou+E%22">Iordanidou E</searchLink>; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.<br /><searchLink fieldCode="AU" term="%22Labrakakis+C%22">Labrakakis C</searchLink>; Department of Biological Applications and Technology, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Pappas+P%22">Pappas P</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Keramidas+AD%22">Keramidas AD</searchLink>; Department of Chemistry, University of Cyprus, Nicosia 2109, Cyprus.<br /><searchLink fieldCode="AU" term="%22Antoniou+K%22">Antoniou K</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Doulias+PT%22">Doulias PT</searchLink>; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Kabanos+TA%22">Kabanos TA</searchLink>; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.<br /><searchLink fieldCode="AU" term="%22Leondaritis+G%22">Leondaritis G</searchLink>; Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; Institute of Biosciences, University Research Center Ioannina, University of Ioannina, Ioannina, Greece. Electronic address: gleondar@uoi.gr.
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