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Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia.

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Title: Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia.
Authors: Chestnykh D; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany., Mühle C; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany., Schumacher F; Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany., Kalinichenko LS; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany., Löber S; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.; FAUNeW-Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany., Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.; FAUNeW-Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany., Alzheimer C; Institute of Physiology and Pathophysiology, Friedrich-Alexander-University of Erlangen-Nuremberg, 91054, Erlangen, Germany., von Hörsten S; Department of Experimental Therapy, Preclinical Experimental Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany., Kleuser B; Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany., Uebe S; Institute of Human Genetics, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany., Ekici AB; Institute of Human Genetics, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany., Gulbins E; Department of Molecular Biology, University of Duisburg-Essen, 45147, Essen, Germany.; Department of Surgery, University of Cincinnati, College of Medicine, University of Cincinnati, Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0558, USA., Kornhuber J; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany., Jin HK; KNU Alzheimer's Disease Research Institute, Kyungpook National University, Daegu, 41566, South Korea.; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, South Korea., Bae JS; KNU Alzheimer's Disease Research Institute, Kyungpook National University, Daegu, 41566, South Korea.; Department of Physiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea., Lourdusamy A; Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK., Müller CP; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany. Christian.Mueller@uk-erlangen.de.; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Christian.Mueller@uk-erlangen.de.
Source: Molecular psychiatry [Mol Psychiatry] 2025 Jul; Vol. 30 (7), pp. 2891-2906. Date of Electronic Publication: 2025 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chestnykh+D%22">Chestnykh D</searchLink>; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Mühle+C%22">Mühle C</searchLink>; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Schumacher+F%22">Schumacher F</searchLink>; Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kalinichenko+LS%22">Kalinichenko LS</searchLink>; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Löber+S%22">Löber S</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.; FAUNeW-Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Gmeiner+P%22">Gmeiner P</searchLink>; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.; FAUNeW-Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Alzheimer+C%22">Alzheimer C</searchLink>; Institute of Physiology and Pathophysiology, Friedrich-Alexander-University of Erlangen-Nuremberg, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22von+Hörsten+S%22">von Hörsten S</searchLink>; Department of Experimental Therapy, Preclinical Experimental Center, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kleuser+B%22">Kleuser B</searchLink>; Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Uebe+S%22">Uebe S</searchLink>; Institute of Human Genetics, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Ekici+AB%22">Ekici AB</searchLink>; Institute of Human Genetics, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Gulbins+E%22">Gulbins E</searchLink>; Department of Molecular Biology, University of Duisburg-Essen, 45147, Essen, Germany.; Department of Surgery, University of Cincinnati, College of Medicine, University of Cincinnati, Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0558, USA.<br /><searchLink fieldCode="AU" term="%22Kornhuber+J%22">Kornhuber J</searchLink>; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Jin+HK%22">Jin HK</searchLink>; KNU Alzheimer's Disease Research Institute, Kyungpook National University, Daegu, 41566, South Korea.; Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, South Korea.<br /><searchLink fieldCode="AU" term="%22Bae+JS%22">Bae JS</searchLink>; KNU Alzheimer's Disease Research Institute, Kyungpook National University, Daegu, 41566, South Korea.; Department of Physiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea.<br /><searchLink fieldCode="AU" term="%22Lourdusamy+A%22">Lourdusamy A</searchLink>; Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.<br /><searchLink fieldCode="AU" term="%22Müller+CP%22">Müller CP</searchLink>; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany. Christian.Mueller@uk-erlangen.de.; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Christian.Mueller@uk-erlangen.de.
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