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Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial.

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Title: Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial.
Authors: Okines AFC; The Royal Marsden NHS Foundation Trust, London, UK., Curigliano G; Istituto Europeo di Oncologia, IRCCS, Milan, Italy.; University of Milano, Milan, Italy., Mizuno N; Aichi Cancer Center Hospital, Nagoya, Japan., Oh DY; Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, South Korea., Rorive A; CHU Sart Tilman Liège, University of Liège, Liège, Belgium., Soliman H; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Takahashi S; Cancer Institute Hospital of JFCR, Tokyo, Japan., Bekaii-Saab T; Mayo Clinic, Scottsdale, AZ, USA., Burkard ME; UW Carbone Cancer Center, University of Wisconsin, Madison, WI, USA., Chung KY; Prisma Health Institute, Greenville, SC, USA., Debruyne PR; Kortrijk Cancer Centre, General Hospital AZ Groeninge, Kortrijk, Belgium.; Medical Technology Research Centre (MTRC), School of Life Sciences, Anglia Ruskin University, Cambridge, UK.; School of Nursing and Midwifery, University of Plymouth, Plymouth, UK., Fox JR; Rocky Mountain Cancer Center, Boulder, CO, USA., Gambardella V; Hospital Clínico Universitario de Valencia, Valencia, Spain., Gil-Martin M; Institut Català d'Oncologia L'Hospitalet-IDIBELL, Hospitalet de Llobregat, Spain., Hamilton EP; Sarah Cannon Research Institute, Nashville, TN, USA., Monk BJ; Florida Cancer Specialists and Research Institute, West Palm Beach, FL, USA., Nakamura Y; National Cancer Center Hospital East, Kashiwa, Japan., Nguyen D; City of Hope National Medical Center, Duarte, CA, USA., O'Malley DM; The Ohio State University and James Comprehensive Cancer Center, Columbus, OH, USA., Olawaiye AB; University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Pothuri B; Laura & Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Reck M; Department of Thoracic Oncology, Airway Research Center North, Germany Center for Lung Disease, Grosshansdorf, Germany., Sudo K; National Cancer Center, Tokyo, Japan., Sunakawa Y; St. Marianna University Hospital, Kawasaki, Japan., Van Marcke C; Cliniques Universitaires Saint-Luc, Brussels, Belgium., Yu EY; Fred Hutchinson Cancer Center/University of Washington, Seattle, WA, USA., Ramos J; Pfizer, Bothell, WA, USA., Tan S; Pfizer, Bothell, WA, USA., Bieda M; Pfizer, Bothell, WA, USA., Stinchcombe TE; Duke Cancer Institute, Durham, NC, USA., Pohlmann PR; University of Texas MD Anderson Cancer Center, Houston, TX, USA. prpohlmann@mdanderson.org.
Source: Nature medicine [Nat Med] 2025 Mar; Vol. 31 (3), pp. 909-916. Date of Electronic Publication: 2025 Jan 17.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Okines+AFC%22">Okines AFC</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Curigliano+G%22">Curigliano G</searchLink>; Istituto Europeo di Oncologia, IRCCS, Milan, Italy.; University of Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mizuno+N%22">Mizuno N</searchLink>; Aichi Cancer Center Hospital, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Oh+DY%22">Oh DY</searchLink>; Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Rorive+A%22">Rorive A</searchLink>; CHU Sart Tilman Liège, University of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Soliman+H%22">Soliman H</searchLink>; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Takahashi+S%22">Takahashi S</searchLink>; Cancer Institute Hospital of JFCR, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Bekaii-Saab+T%22">Bekaii-Saab T</searchLink>; Mayo Clinic, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Burkard+ME%22">Burkard ME</searchLink>; UW Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Chung+KY%22">Chung KY</searchLink>; Prisma Health Institute, Greenville, SC, USA.<br /><searchLink fieldCode="AU" term="%22Debruyne+PR%22">Debruyne PR</searchLink>; Kortrijk Cancer Centre, General Hospital AZ Groeninge, Kortrijk, Belgium.; Medical Technology Research Centre (MTRC), School of Life Sciences, Anglia Ruskin University, Cambridge, UK.; School of Nursing and Midwifery, University of Plymouth, Plymouth, UK.<br /><searchLink fieldCode="AU" term="%22Fox+JR%22">Fox JR</searchLink>; Rocky Mountain Cancer Center, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Gambardella+V%22">Gambardella V</searchLink>; Hospital Clínico Universitario de Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Gil-Martin+M%22">Gil-Martin M</searchLink>; Institut Català d'Oncologia L'Hospitalet-IDIBELL, Hospitalet de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Hamilton+EP%22">Hamilton EP</searchLink>; Sarah Cannon Research Institute, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Monk+BJ%22">Monk BJ</searchLink>; Florida Cancer Specialists and Research Institute, West Palm Beach, FL, USA.<br /><searchLink fieldCode="AU" term="%22Nakamura+Y%22">Nakamura Y</searchLink>; National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Nguyen+D%22">Nguyen D</searchLink>; City of Hope National Medical Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22O'Malley+DM%22">O'Malley DM</searchLink>; The Ohio State University and James Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Olawaiye+AB%22">Olawaiye AB</searchLink>; University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pothuri+B%22">Pothuri B</searchLink>; Laura & Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Reck+M%22">Reck M</searchLink>; Department of Thoracic Oncology, Airway Research Center North, Germany Center for Lung Disease, Grosshansdorf, Germany.<br /><searchLink fieldCode="AU" term="%22Sudo+K%22">Sudo K</searchLink>; National Cancer Center, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sunakawa+Y%22">Sunakawa Y</searchLink>; St. Marianna University Hospital, Kawasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Van+Marcke+C%22">Van Marcke C</searchLink>; Cliniques Universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Yu+EY%22">Yu EY</searchLink>; Fred Hutchinson Cancer Center/University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ramos+J%22">Ramos J</searchLink>; Pfizer, Bothell, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+S%22">Tan S</searchLink>; Pfizer, Bothell, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bieda+M%22">Bieda M</searchLink>; Pfizer, Bothell, WA, USA.<br /><searchLink fieldCode="AU" term="%22Stinchcombe+TE%22">Stinchcombe TE</searchLink>; Duke Cancer Institute, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pohlmann+PR%22">Pohlmann PR</searchLink>; University of Texas MD Anderson Cancer Center, Houston, TX, USA. prpohlmann@mdanderson.org.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 Mar; Vol. 31 (3), pp. 909-916. <i>Date of Electronic Publication: </i>2025 Jan 17.
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