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Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells.

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Title: Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells.
Authors: Young KS; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Hancock GR; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Fink EC; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Zigrossi A; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Flowers B; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Cooper DA; Department of Chemistry, Illinois Institute of Technology, Chicago, IL, 60616, USA., Nguyen VT; Department of Chemistry, Illinois Institute of Technology, Chicago, IL, 60616, USA., Martinez MC; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Mon KS; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Bosland M; Department of Pathology, University of Illinois Chicago, Chicago, IL, 60607, USA., Zak DR; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Runde AP; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Sharifi MN; Department of Medicine, University of Wisconsin, Madison, WI, 53705, USA., Kastrati I; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Minh DDL; Department of Chemistry, Illinois Institute of Technology, Chicago, IL, 60616, USA., Kregel S; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA., Fanning SW; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA. sfanning@luc.edu.
Source: Breast cancer research : BCR [Breast Cancer Res] 2025 Jan 17; Vol. 27 (1), pp. 10. Date of Electronic Publication: 2025 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE
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  Data: Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Young+KS%22">Young KS</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Hancock+GR%22">Hancock GR</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Fink+EC%22">Fink EC</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Zigrossi+A%22">Zigrossi A</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Flowers+B%22">Flowers B</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Cooper+DA%22">Cooper DA</searchLink>; Department of Chemistry, Illinois Institute of Technology, Chicago, IL, 60616, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+VT%22">Nguyen VT</searchLink>; Department of Chemistry, Illinois Institute of Technology, Chicago, IL, 60616, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+MC%22">Martinez MC</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Mon+KS%22">Mon KS</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Bosland+M%22">Bosland M</searchLink>; Department of Pathology, University of Illinois Chicago, Chicago, IL, 60607, USA.<br /><searchLink fieldCode="AU" term="%22Zak+DR%22">Zak DR</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Runde+AP%22">Runde AP</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Sharifi+MN%22">Sharifi MN</searchLink>; Department of Medicine, University of Wisconsin, Madison, WI, 53705, USA.<br /><searchLink fieldCode="AU" term="%22Kastrati+I%22">Kastrati I</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Minh+DDL%22">Minh DDL</searchLink>; Department of Chemistry, Illinois Institute of Technology, Chicago, IL, 60616, USA.<br /><searchLink fieldCode="AU" term="%22Kregel+S%22">Kregel S</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA.<br /><searchLink fieldCode="AU" term="%22Fanning+SW%22">Fanning SW</searchLink>; Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 50153, USA. sfanning@luc.edu.
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  Data: <searchLink fieldCode="JN" term="%22100927353%22">Breast cancer research : BCR</searchLink> [Breast Cancer Res] 2025 Jan 17; Vol. 27 (1), pp. 10. <i>Date of Electronic Publication: </i>2025 Jan 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100927353 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1465-542X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214655411%22">14655411 </searchLink><i>NLM ISO Abbreviation: </i>Breast Cancer Res <i>Subsets: </i>MEDLINE
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