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Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing.

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Title: Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing.
Authors: Cöllen E; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany., Bartmann K; DNTOX GmbH, Düsseldorf, Germany.; IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany., Blum J; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany., Carstens K; Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA., Celardo I; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany., Chatterjee N; NanoSafety Group, International Iberian Nanotechnology Laboratory, Braga, Portugal., Corvaro M; Corteva Agriscience Italia, S.r.l., Rome, Italy., Dreser N; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany., Fritsche E; DNTOX GmbH, Düsseldorf, Germany.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; SCAHT - Swiss Centre for Applied Human Toxicology, Basel, Switzerland., Hartung T; Center for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.; CAAT-Europe, University of Konstanz, Konstanz, Germany., Hogberg HT; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Knudsen T; US EPA Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA (retired)., Koch K; DNTOX GmbH, Düsseldorf, Germany.; IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany., Kreutz A; Inotiv, Morrisville, NC, USA., Lislien M; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway., Magel V; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany., Marty MS; Dow Chemical Company, Midland, MI, USA., Pallocca G; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany., Bal-Price A; European Commission Joint Research Centre, Ispra, Italy., Rovida C; CAAT-Europe, University of Konstanz, Konstanz, Germany., Sachana M; Environment Health and Safety Division, Environment Directorate, Organisation for Economic Cooperation and Development (OECD), Paris, France., Shafer TJ; Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA., Smirnova L; Center for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Suciu I; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany., Tanaskov Y; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany., Tangianu S; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany., Wolfbeisz C; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany., Leist M; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany.
Source: ALTEX [ALTEX] 2025; Vol. 42 (2), pp. 308-322. Date of Electronic Publication: 2025 Jan 14.
Publication Type: Journal Article
Journal Info: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE
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  Data: Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing.
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  Data: <searchLink fieldCode="AU" term="%22Cöllen+E%22">Cöllen E</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany.<br /><searchLink fieldCode="AU" term="%22Bartmann+K%22">Bartmann K</searchLink>; DNTOX GmbH, Düsseldorf, Germany.; IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Blum+J%22">Blum J</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Carstens+K%22">Carstens K</searchLink>; Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Celardo+I%22">Celardo I</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Chatterjee+N%22">Chatterjee N</searchLink>; NanoSafety Group, International Iberian Nanotechnology Laboratory, Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Corvaro+M%22">Corvaro M</searchLink>; Corteva Agriscience Italia, S.r.l., Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Dreser+N%22">Dreser N</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Fritsche+E%22">Fritsche E</searchLink>; DNTOX GmbH, Düsseldorf, Germany.; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; SCAHT - Swiss Centre for Applied Human Toxicology, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hartung+T%22">Hartung T</searchLink>; Center for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.; CAAT-Europe, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Hogberg+HT%22">Hogberg HT</searchLink>; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Knudsen+T%22">Knudsen T</searchLink>; US EPA Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA (retired).<br /><searchLink fieldCode="AU" term="%22Koch+K%22">Koch K</searchLink>; DNTOX GmbH, Düsseldorf, Germany.; IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kreutz+A%22">Kreutz A</searchLink>; Inotiv, Morrisville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lislien+M%22">Lislien M</searchLink>; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Magel+V%22">Magel V</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany.<br /><searchLink fieldCode="AU" term="%22Marty+MS%22">Marty MS</searchLink>; Dow Chemical Company, Midland, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pallocca+G%22">Pallocca G</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Bal-Price+A%22">Bal-Price A</searchLink>; European Commission Joint Research Centre, Ispra, Italy.<br /><searchLink fieldCode="AU" term="%22Rovida+C%22">Rovida C</searchLink>; CAAT-Europe, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Sachana+M%22">Sachana M</searchLink>; 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INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany.<br /><searchLink fieldCode="AU" term="%22Tangianu+S%22">Tangianu S</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Wolfbeisz+C%22">Wolfbeisz C</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; INVITE-2, Graduate school of the LBW for in vitro technologies, Konstanz-Sigmaringen, Germany.<br /><searchLink fieldCode="AU" term="%22Leist+M%22">Leist M</searchLink>; In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, University of Konstanz, Konstanz, Germany.
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