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Pembrolizumab with or without bevacizumab in platinum-resistant recurrent or metastatic nasopharyngeal carcinoma: a randomised, open-label, phase 2 trial.

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Title: Pembrolizumab with or without bevacizumab in platinum-resistant recurrent or metastatic nasopharyngeal carcinoma: a randomised, open-label, phase 2 trial.
Authors: Chong WQ; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Low JL; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Tay JK; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore; Department of Otolaryngology, Head and Neck Surgery, National University of Singapore, Singapore., Le TBU; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Goh GS; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Sooi K; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Teo HL; Department of Medical Oncology, Tan Tock Seng Hospital, Singapore., Cheo SW; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Wong RT; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Samol J; Department of Medical Oncology, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Singapore; School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Lim MY; Department of Otorhinolaryngology and Head and Neck Surgery, Tan Tock Seng Hospital, Singapore., Li H; Department of Otorhinolaryngology and Head and Neck Surgery, Tan Tock Seng Hospital, Singapore., Shirgaonkar N; Genome Institute of Singapore, Agency of Science, Technology and Research, Singapore., Chia S; Genome Institute of Singapore, Agency of Science, Technology and Research, Singapore., Wang L; Department of Pharmacology, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Gopinathan A; Department of Diagnostic Imaging, National University Hospital, Singapore., Eu DK; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore., Tsang RK; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore; Department of Otolaryngology, Head and Neck Surgery, National University of Singapore, Singapore., Loh KS; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore; Department of Otolaryngology, Head and Neck Surgery, National University of Singapore, Singapore., Toh HC; National Cancer Centre, Singapore., Syn N; Department of Pathology, National University of Singapore, Singapore., Kong LR; Department of Pharmacology, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Dasgupta R; Genome Institute of Singapore, Agency of Science, Technology and Research, Singapore., Tai BC; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Lim YC; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Goh BC; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Department of Pharmacology, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address: phcgbc@nus.edu.sg.
Source: The Lancet. Oncology [Lancet Oncol] 2025 Feb; Vol. 26 (2), pp. 175-186. Date of Electronic Publication: 2025 Jan 15.
Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pembrolizumab with or without bevacizumab in platinum-resistant recurrent or metastatic nasopharyngeal carcinoma: a randomised, open-label, phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Chong+WQ%22">Chong WQ</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Low+JL%22">Low JL</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+JK%22">Tay JK</searchLink>; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore; Department of Otolaryngology, Head and Neck Surgery, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Le+TBU%22">Le TBU</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+GS%22">Goh GS</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sooi+K%22">Sooi K</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Teo+HL%22">Teo HL</searchLink>; Department of Medical Oncology, Tan Tock Seng Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheo+SW%22">Cheo SW</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+RT%22">Wong RT</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Samol+J%22">Samol J</searchLink>; Department of Medical Oncology, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Singapore; School of Medicine, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lim+MY%22">Lim MY</searchLink>; Department of Otorhinolaryngology and Head and Neck Surgery, Tan Tock Seng Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Otorhinolaryngology and Head and Neck Surgery, Tan Tock Seng Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Shirgaonkar+N%22">Shirgaonkar N</searchLink>; Genome Institute of Singapore, Agency of Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Chia+S%22">Chia S</searchLink>; Genome Institute of Singapore, Agency of Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Pharmacology, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Gopinathan+A%22">Gopinathan A</searchLink>; Department of Diagnostic Imaging, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Eu+DK%22">Eu DK</searchLink>; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Tsang+RK%22">Tsang RK</searchLink>; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore; Department of Otolaryngology, Head and Neck Surgery, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Loh+KS%22">Loh KS</searchLink>; Department of Otolaryngology, Head and Neck Surgery, National University Hospital, Singapore; Department of Otolaryngology, Head and Neck Surgery, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Toh+HC%22">Toh HC</searchLink>; National Cancer Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Syn+N%22">Syn N</searchLink>; Department of Pathology, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kong+LR%22">Kong LR</searchLink>; Department of Pharmacology, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Dasgupta+R%22">Dasgupta R</searchLink>; Genome Institute of Singapore, Agency of Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Tai+BC%22">Tai BC</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+YC%22">Lim YC</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+BC%22">Goh BC</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Department of Pharmacology, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address: phcgbc@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2025 Feb; Vol. 26 (2), pp. 175-186. <i>Date of Electronic Publication: </i>2025 Jan 15.
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  Data: Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE
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              Text: 2025 Feb
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