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Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare.

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Title: Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare.
Authors: Marx U; TissUse GmbH, Berlin, Germany.; Technische Universitaet Berlin, Berlin, Germany., Beken S; Federal Agency for Medicines and Health Products, Brussels, Belgium., Chen Z; School of Biological Science and Medical Engineering of Southeast University, Nanjing, China., Dehne EM; TissUse GmbH, Berlin, Germany., Doherty A; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, UK., Ewart L; Emulate Inc., Boston, MA, USA., Fitzpatrick SC; US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA., Griffith LG; Massachusetts Institute of Technology, Cambridge, MA, USA., Gu Z; School of Biological Science and Medical Engineering of Southeast University, Nanjing, China.; JITRI Institute of Biomaterials and Biomedical Devices, Nanjing, China., Hartung T; Center for Alternatives to Animal Testing, Bloomberg School of Public Health and Whiting School of Engineering, Doerenkamp-Zbinden-Chair for Evidence-based Toxicology, Johns Hopkins University, Baltimore, MD, USA.; Center for Alternatives to Animal Testing in Europe, University of Konstanz, Konstanz, Germany., Hickman J; Hesperos Inc., Orlando, FL, USA., Ingber DE; Wyss Institute for Biology Inspired Engineering, Harvard University, Boston, MA, USA., Ishida S; National Institute of Health Sciences, Kawasaki, Japan.; Graduate School of Engineering, Sojo University, Kumamoto, Japan., Jeong J; KBIOHealth, Chungcheongbuk-do, South Korea., Leist M; Center for Alternatives to Animal Testing in Europe, University of Konstanz, Konstanz, Germany., Levin L; Philanthropy New York, NY, USA., Mendrick DL; National Center for Toxicological Research, FDA, Silver Spring, MD, USA., Pallocca G; Humane Society International/Europe, Brussels, Belgium., Platz S; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, UK., Raschke M; Bayer Pharma AG, Preclinical Development, Berlin, Germany., Smirnova L; Center for Alternatives to Animal Testing, Bloomberg School of Public Health and Whiting School of Engineering, Doerenkamp-Zbinden-Chair for Evidence-based Toxicology, Johns Hopkins University, Baltimore, MD, USA., Tagle DA; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA., Trapecar M; Johns Hopkins University School of Medicine, Baltimore, MD, USA., van Balkom BWM; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., van den Eijnden-van Raaij J; Institute for Human Organ and Disease Model Technologies, Eindhoven, The Netherlands., van der Meer A; Faculty of Science and Technology, University of Twente, Twente, The Netherlands., Roth A; F. Hoffmann-La Roche Ltd, Precision Safety, Product Development, Basel, Switzerland.
Source: ALTEX [ALTEX] 2025; Vol. 42 (2), pp. 204-223. Date of Electronic Publication: 2025 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE
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  Data: Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare.
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  Data: <searchLink fieldCode="AU" term="%22Marx+U%22">Marx U</searchLink>; TissUse GmbH, Berlin, Germany.; Technische Universitaet Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Beken+S%22">Beken S</searchLink>; Federal Agency for Medicines and Health Products, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; School of Biological Science and Medical Engineering of Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Dehne+EM%22">Dehne EM</searchLink>; TissUse GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Doherty+A%22">Doherty A</searchLink>; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ewart+L%22">Ewart L</searchLink>; Emulate Inc., Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fitzpatrick+SC%22">Fitzpatrick SC</searchLink>; US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA.<br /><searchLink fieldCode="AU" term="%22Griffith+LG%22">Griffith LG</searchLink>; Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gu+Z%22">Gu Z</searchLink>; School of Biological Science and Medical Engineering of Southeast University, Nanjing, China.; JITRI Institute of Biomaterials and Biomedical Devices, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Hartung+T%22">Hartung T</searchLink>; Center for Alternatives to Animal Testing, Bloomberg School of Public Health and Whiting School of Engineering, Doerenkamp-Zbinden-Chair for Evidence-based Toxicology, Johns Hopkins University, Baltimore, MD, USA.; Center for Alternatives to Animal Testing in Europe, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Hickman+J%22">Hickman J</searchLink>; Hesperos Inc., Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ingber+DE%22">Ingber DE</searchLink>; Wyss Institute for Biology Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ishida+S%22">Ishida S</searchLink>; National Institute of Health Sciences, Kawasaki, Japan.; Graduate School of Engineering, Sojo University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Jeong+J%22">Jeong J</searchLink>; KBIOHealth, Chungcheongbuk-do, South Korea.<br /><searchLink fieldCode="AU" term="%22Leist+M%22">Leist M</searchLink>; Center for Alternatives to Animal Testing in Europe, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Levin+L%22">Levin L</searchLink>; Philanthropy New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mendrick+DL%22">Mendrick DL</searchLink>; National Center for Toxicological Research, FDA, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Pallocca+G%22">Pallocca G</searchLink>; Humane Society International/Europe, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Platz+S%22">Platz S</searchLink>; Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Raschke+M%22">Raschke M</searchLink>; Bayer Pharma AG, Preclinical Development, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Smirnova+L%22">Smirnova L</searchLink>; Center for Alternatives to Animal Testing, Bloomberg School of Public Health and Whiting School of Engineering, Doerenkamp-Zbinden-Chair for Evidence-based Toxicology, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tagle+DA%22">Tagle DA</searchLink>; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Trapecar+M%22">Trapecar M</searchLink>; Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22van+Balkom+BWM%22">van Balkom BWM</searchLink>; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Eijnden-van+Raaij+J%22">van den Eijnden-van Raaij J</searchLink>; Institute for Human Organ and Disease Model Technologies, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Meer+A%22">van der Meer A</searchLink>; Faculty of Science and Technology, University of Twente, Twente, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Roth+A%22">Roth A</searchLink>; F. Hoffmann-La Roche Ltd, Precision Safety, Product Development, Basel, Switzerland.
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