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Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.

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Title: Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.
Authors: Ufnal M; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Warsaw, Poland., Connolly K; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Millegard M; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Surkova E; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Guazzi M; University of Milan School of Medicine, San Paolo University Hospital, Milan, Italy., Bonderman D; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Ezekowitz J; Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada., Gustafsson F; The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ciurzyński M; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland., Vilella RL; Heart Failure and Transplantation Unit, La Fe University and Polytechnic Hospital, Valencia, Spain., Ahmad T; Heart Failure Program, Yale School of Medicine, New Haven, Connecticut, USA., Gardner R; Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Clydebank, UK., Jansa P; 2nd Department of Medicine, Charles University and General University Hospital, Prague, Czechia., van Wijk S; Department of Cardiology, Zuyderland Medical Center, Heerlen, The Netherlands., Kinugawa K; Second Department of Internal Medicine, University of Toyama, Toyama, Japan., Björklund E; Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden., Jing ZC; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Rosenkranz S; Department of Cardiology, Pulmonology, and Intensive Care Medicine, Center for Molecular Medicine Cologne (CMMC), Cologne Cardiovascular Research Center (CCRC), Medical Faculty, University of Cologne, Cologne, Germany.
Source: ESC heart failure [ESC Heart Fail] 2025 Jun; Vol. 12 (3), pp. 1956-1964. Date of Electronic Publication: 2025 Jan 20.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.
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  Data: <searchLink fieldCode="AU" term="%22Ufnal+M%22">Ufnal M</searchLink>; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Connolly+K%22">Connolly K</searchLink>; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Millegard+M%22">Millegard M</searchLink>; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Surkova+E%22">Surkova E</searchLink>; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Guazzi+M%22">Guazzi M</searchLink>; University of Milan School of Medicine, San Paolo University Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonderman+D%22">Bonderman D</searchLink>; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Ezekowitz+J%22">Ezekowitz J</searchLink>; Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Gustafsson+F%22">Gustafsson F</searchLink>; The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ciurzyński+M%22">Ciurzyński M</searchLink>; Department of Internal Medicine and Cardiology with the Centre for Management of Venous Thromboembolic Disease, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Vilella+RL%22">Vilella RL</searchLink>; Heart Failure and Transplantation Unit, La Fe University and Polytechnic Hospital, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ahmad+T%22">Ahmad T</searchLink>; Heart Failure Program, Yale School of Medicine, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Gardner+R%22">Gardner R</searchLink>; Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Clydebank, UK.<br /><searchLink fieldCode="AU" term="%22Jansa+P%22">Jansa P</searchLink>; 2nd Department of Medicine, Charles University and General University Hospital, Prague, Czechia.<br /><searchLink fieldCode="AU" term="%22van+Wijk+S%22">van Wijk S</searchLink>; Department of Cardiology, Zuyderland Medical Center, Heerlen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kinugawa+K%22">Kinugawa K</searchLink>; Second Department of Internal Medicine, University of Toyama, Toyama, Japan.<br /><searchLink fieldCode="AU" term="%22Björklund+E%22">Björklund E</searchLink>; Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Jing+ZC%22">Jing ZC</searchLink>; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Rosenkranz+S%22">Rosenkranz S</searchLink>; Department of Cardiology, Pulmonology, and Intensive Care Medicine, Center for Molecular Medicine Cologne (CMMC), Cologne Cardiovascular Research Center (CCRC), Medical Faculty, University of Cologne, Cologne, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101669191%22">ESC heart failure</searchLink> [ESC Heart Fail] 2025 Jun; Vol. 12 (3), pp. 1956-1964. <i>Date of Electronic Publication: </i>2025 Jan 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons+Ltd+on+behalf+of+the+European+Society+of+Cardiology%22">John Wiley & Sons Ltd on behalf of the European Society of Cardiology </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101669191 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2055-5822 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220555822%22">20555822 </searchLink><i>NLM ISO Abbreviation: </i>ESC Heart Fail <i>Subsets: </i>MEDLINE
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        Value: 10.1002/ehf2.15203
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      – Code: eng
        Text: English
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        StartPage: 1956
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      – TitleFull: Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.
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              Text: 2025 Jun
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