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Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition.

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Title: Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition.
Authors: Chen X; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.; These authors contributed equally., Diessel Duan H; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.; These authors contributed equally., Hoy MJ; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Koteva K; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Spitzer M; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Guitor AK; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Puumala E; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Fiebig AA; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Hu G; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Yiu B; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Chou S; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Bian Z; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Choi Y; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Guo ABY; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Wang W; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Sun S; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Robbins N; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Averette AF; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Cook MA; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Truant R; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada., MacNeil LT; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada., Brown ED; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Kronstad JW; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Coombes BK; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada., Cowen LE; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5G 1M1, Canada., Heitman J; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA., Li H; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Wright GD; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.; Lead contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 29. Date of Electronic Publication: 2025 Jul 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Diessel+Duan+H%22">Diessel Duan H</searchLink>; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Hoy+MJ%22">Hoy MJ</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Koteva+K%22">Koteva K</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Spitzer+M%22">Spitzer M</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Guitor+AK%22">Guitor AK</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. 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DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Sun+S%22">Sun S</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+N%22">Robbins N</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5G 1M1, Canada.<br /><searchLink fieldCode="AU" term="%22Averette+AF%22">Averette AF</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Cook+MA%22">Cook MA</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Truant+R%22">Truant R</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.<br /><searchLink fieldCode="AU" term="%22MacNeil+LT%22">MacNeil LT</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.<br /><searchLink fieldCode="AU" term="%22Brown+ED%22">Brown ED</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Kronstad+JW%22">Kronstad JW</searchLink>; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Coombes+BK%22">Coombes BK</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Cowen+LE%22">Cowen LE</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5G 1M1, Canada.<br /><searchLink fieldCode="AU" term="%22Heitman+J%22">Heitman J</searchLink>; Department of Molecular Genetics and Microbiology, Duke University, Duke University Medical Center, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Wright+GD%22">Wright GD</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.; Lead contact.
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