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The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.

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Title: The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.
Authors: Watts B; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia., Smith CM; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia., Evans K; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia., Gifford AJ; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.; Anatomical Pathology, NSW Health Pathology Prince of Wales Hospital Randwick New South Wales Australia.; School of Clinical Medicine, UNSW Medicine & Health UNSW Sydney Sydney New South Wales Australia., Mohamed SMA; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.; Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy, Ain Shams University Cairo Egypt., Erickson SW; RTI International Research Triangle Park North Carolina USA., Earley EJ; RTI International Research Triangle Park North Carolina USA., Neuhauser S; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Stearns TM; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Philip VM; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Chuang JH; The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA., Zweidler-McKay PA; ImmunoGen, Inc. Waltham Massachusetts USA., Lakshmikanthan S; ImmunoGen, Inc. Waltham Massachusetts USA., Jocoy EL; The Jackson Laboratory Sacramento California USA., Bult CJ; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Teicher BA; National Cancer Institute Bethesda Maryland USA., Smith MA; National Cancer Institute Bethesda Maryland USA., Lock RB; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.
Source: HemaSphere [Hemasphere] 2025 Jan 17; Vol. 9 (1), pp. e70063. Date of Electronic Publication: 2025 Jan 17 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
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  Data: The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Watts+B%22">Watts B</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Smith+CM%22">Smith CM</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Evans+K%22">Evans K</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Gifford+AJ%22">Gifford AJ</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.; Anatomical Pathology, NSW Health Pathology Prince of Wales Hospital Randwick New South Wales Australia.; School of Clinical Medicine, UNSW Medicine & Health UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Mohamed+SMA%22">Mohamed SMA</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.; Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy, Ain Shams University Cairo Egypt.<br /><searchLink fieldCode="AU" term="%22Erickson+SW%22">Erickson SW</searchLink>; RTI International Research Triangle Park North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Earley+EJ%22">Earley EJ</searchLink>; RTI International Research Triangle Park North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Neuhauser+S%22">Neuhauser S</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Stearns+TM%22">Stearns TM</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Philip+VM%22">Philip VM</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Chuang+JH%22">Chuang JH</searchLink>; The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA.<br /><searchLink fieldCode="AU" term="%22Zweidler-McKay+PA%22">Zweidler-McKay PA</searchLink>; ImmunoGen, Inc. Waltham Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Lakshmikanthan+S%22">Lakshmikanthan S</searchLink>; ImmunoGen, Inc. Waltham Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Jocoy+EL%22">Jocoy EL</searchLink>; The Jackson Laboratory Sacramento California USA.<br /><searchLink fieldCode="AU" term="%22Bult+CJ%22">Bult CJ</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Teicher+BA%22">Teicher BA</searchLink>; National Cancer Institute Bethesda Maryland USA.<br /><searchLink fieldCode="AU" term="%22Smith+MA%22">Smith MA</searchLink>; National Cancer Institute Bethesda Maryland USA.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research UNSW Sydney Sydney New South Wales Australia.
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