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Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2.

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Title: Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2.
Authors: Tang CL; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Li YQ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Du XK; Center for Systems Biology, Department of Bioinformatics, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China., Fang XX; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China., Guang YM; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Li PZ; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Chen S; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China., Xue SY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yu JM; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Liu XY; Center for Systems Biology, Department of Bioinformatics, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China., Luo YP; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China., Zhou LX; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China., Luo C; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China., Xiong H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. xionghuan@zidd.ac.cn.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. xionghuan@zidd.ac.cn., Liang ZJ; Center for Systems Biology, Department of Bioinformatics, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China. zjliang@suda.edu.cn.; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou, 215123, China. zjliang@suda.edu.cn., Ding H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. hding@simm.ac.cn.; School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China. hding@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 May; Vol. 46 (5), pp. 1476-1491. Date of Electronic Publication: 2025 Jan 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2.
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  Data: <searchLink fieldCode="AU" term="%22Tang+CL%22">Tang CL</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+YQ%22">Li YQ</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Du+XK%22">Du XK</searchLink>; Center for Systems Biology, Department of Bioinformatics, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Fang+XX%22">Fang XX</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.<br /><searchLink fieldCode="AU" term="%22Guang+YM%22">Guang YM</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+PZ%22">Li PZ</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.<br /><searchLink fieldCode="AU" term="%22Xue+SY%22">Xue SY</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Yu+JM%22">Yu JM</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+XY%22">Liu XY</searchLink>; Center for Systems Biology, Department of Bioinformatics, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Luo+YP%22">Luo YP</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.<br /><searchLink fieldCode="AU" term="%22Zhou+LX%22">Zhou LX</searchLink>; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.<br /><searchLink fieldCode="AU" term="%22Luo+C%22">Luo C</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.; School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.<br /><searchLink fieldCode="AU" term="%22Xiong+H%22">Xiong H</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. xionghuan@zidd.ac.cn.; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. xionghuan@zidd.ac.cn.<br /><searchLink fieldCode="AU" term="%22Liang+ZJ%22">Liang ZJ</searchLink>; Center for Systems Biology, Department of Bioinformatics, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China. zjliang@suda.edu.cn.; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou, 215123, China. zjliang@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ding+H%22">Ding H</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. hding@simm.ac.cn.; School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China. hding@simm.ac.cn.
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        Value: 10.1038/s41401-024-01452-z
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