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Robust Diagnosis of Acute Bacterial and Viral Infections via Host Gene Expression Rank-Based Ensemble Machine Learning Algorithm: A Multi-Cohort Model Development and Validation Study.

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Title: Robust Diagnosis of Acute Bacterial and Viral Infections via Host Gene Expression Rank-Based Ensemble Machine Learning Algorithm: A Multi-Cohort Model Development and Validation Study.
Authors: Shen Y; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China., Han D; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China., Qu W; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China., Yu F; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China., Zhang D; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China., Xu Y; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Shen E; Institute of Bioinformatics, Zhejiang University, Hangzhou, China., Chu Q; Institute of Bioinformatics, Zhejiang University, Hangzhou, China., Timko MP; Departments of Biology and Public Health Sciences, University of Virginia, Charlottesville, VA, United States., Fan L; Institute of Bioinformatics, Zhejiang University, Hangzhou, China., Zheng S; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen Y; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Source: Clinical chemistry [Clin Chem] 2025 Apr 03; Vol. 71 (4), pp. 497-509.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9421549 Publication Model: Print Cited Medium: Internet ISSN: 1530-8561 (Electronic) Linking ISSN: 00099147 NLM ISO Abbreviation: Clin Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Robust Diagnosis of Acute Bacterial and Viral Infections via Host Gene Expression Rank-Based Ensemble Machine Learning Algorithm: A Multi-Cohort Model Development and Validation Study.
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  Data: <searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Han+D%22">Han D</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Qu+W%22">Qu W</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yu+F%22">Yu F</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+E%22">Shen E</searchLink>; Institute of Bioinformatics, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chu+Q%22">Chu Q</searchLink>; Institute of Bioinformatics, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Timko+MP%22">Timko MP</searchLink>; Departments of Biology and Public Health Sciences, University of Virginia, Charlottesville, VA, United States.<br /><searchLink fieldCode="AU" term="%22Fan+L%22">Fan L</searchLink>; Institute of Bioinformatics, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+S%22">Zheng S</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University, Hangzhou, China.; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
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              Text: 2025 Apr 03
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