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Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer.

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Title: Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer.
Authors: Belabed M; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Park MD; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Blouin CM; Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Centre de Recherche, Institut Curie, PSL Research University, Paris, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.; Centre National de la Recherche Scientifique, Paris, France., Balan S; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Moon CY; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Freed G; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Quijada-Álamo M; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Peros A; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mattiuz R; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Reid AM; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yatim N; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Boumelha J; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Azimi CS; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., LaMarche NM; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Troncoso L; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Amabile A; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Le Berichel J; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen ST; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wilk CM; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brown BD; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Radford KJ; Mater Research Institute, the University of Queensland, Brisbane, Queensland, Australia., Ghosh S; Department of Immunobiology and Department of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT, USA., Rothlin CV; Department of Neurology and Department of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT, USA., Yvan-Charvet L; INSERM U1065, ATIP-Avenir, Fédération Hospitalo-Universitaire OncoAge, Université Côte d'Azur, Centre Méditerranéen de Médecine Moléculaire (C3M), Nice, France., Marron TU; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Thoracic Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Puleston DJ; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wagenblast E; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bhardwaj N; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lamaze C; Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Centre de Recherche, Institut Curie, PSL Research University, Paris, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.; Centre National de la Recherche Scientifique, Paris, France., Merad M; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. miriam.merad@mssm.edu.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. miriam.merad@mssm.edu.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. miriam.merad@mssm.edu.
Source: Nature immunology [Nat Immunol] 2025 Feb; Vol. 26 (2), pp. 188-199. Date of Electronic Publication: 2025 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer.
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