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De novo design of peptide binders to conformationally diverse targets with contrastive language modeling.

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Title: De novo design of peptide binders to conformationally diverse targets with contrastive language modeling.
Authors: Bhat S; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Palepu K; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Hong L; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Mao J; Department of Cell Biology, Duke University, Durham, NC, USA., Ye T; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA., Iyer R; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA., Zhao L; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Chen T; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Vincoff S; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Watson R; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Wang TZ; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Srijay D; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Kavirayuni VS; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Kholina K; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Goel S; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Vure P; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Deshpande AJ; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA., Soderling SH; Department of Cell Biology, Duke University, Durham, NC, USA., DeLisa MP; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY, USA., Chatterjee P; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Department of Computer Science, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
Source: Science advances [Sci Adv] 2025 Jan 24; Vol. 11 (4), pp. eadr8638. Date of Electronic Publication: 2025 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Bhat+S%22">Bhat S</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Palepu+K%22">Palepu K</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hong+L%22">Hong L</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mao+J%22">Mao J</searchLink>; Department of Cell Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ye+T%22">Ye T</searchLink>; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Iyer+R%22">Iyer R</searchLink>; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Vincoff+S%22">Vincoff S</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Watson+R%22">Watson R</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wang+TZ%22">Wang TZ</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Srijay+D%22">Srijay D</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kavirayuni+VS%22">Kavirayuni VS</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kholina+K%22">Kholina K</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Goel+S%22">Goel S</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Vure+P%22">Vure P</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Deshpande+AJ%22">Deshpande AJ</searchLink>; Cancer Genome and Epigenetics Program, Sanford Burnham Prebys Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Soderling+SH%22">Soderling SH</searchLink>; Department of Cell Biology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22DeLisa+MP%22">DeLisa MP</searchLink>; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chatterjee+P%22">Chatterjee P</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Department of Computer Science, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2025 Jan 24; Vol. 11 (4), pp. eadr8638. <i>Date of Electronic Publication: </i>2025 Jan 22.
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