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Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia.

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Title: Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia.
Authors: Tremblay CS; Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada. cedric.tremblay@umanitoba.ca.; Paul Albrechtsen Research Institute CancerCare Manitoba, Winnipeg, MB, Canada. cedric.tremblay@umanitoba.ca.; Children's Hospital Research Institute of Manitoba (CHRIM), Winnipeg, MB, Canada. cedric.tremblay@umanitoba.ca.; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia. cedric.tremblay@umanitoba.ca., Saw J; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Yan F; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Bioinformatics Division, Walter and Eliza Hall Institute (WEHI) of Medical Research, Parkville, VIC, Australia., Boyle JA; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Amarasinghe O; Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.; Paul Albrechtsen Research Institute CancerCare Manitoba, Winnipeg, MB, Canada., Abdollahi S; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Vo ANQ; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Shields BJ; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Mayoh C; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., McCalmont H; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., Evans K; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., Steiner A; Paul Albrechtsen Research Institute CancerCare Manitoba, Winnipeg, MB, Canada.; Community and Researcher Engagement (CaRE) program, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Women in Lymphoma, Lymphoma Australia, Brisbane, QLD, Australia., Parsons K; Community and Researcher Engagement (CaRE) program, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., McCormack MP; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Powell DR; Monash Bioinformatics Platform, Monash University, Clayton, VIC, Australia., Wong NC; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Monash Bioinformatics Platform, Monash University, Clayton, VIC, Australia., Jane SM; Department of Medicine, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Lock RB; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., Curtis DJ; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Department of Clinical Haematology, Alfred Hospital, Prahran, VIC, Australia.
Source: Leukemia [Leukemia] 2025 Mar; Vol. 39 (3), pp. 577-589. Date of Electronic Publication: 2025 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Tremblay+CS%22">Tremblay CS</searchLink>; Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada. cedric.tremblay@umanitoba.ca.; Paul Albrechtsen Research Institute CancerCare Manitoba, Winnipeg, MB, Canada. cedric.tremblay@umanitoba.ca.; Children's Hospital Research Institute of Manitoba (CHRIM), Winnipeg, MB, Canada. cedric.tremblay@umanitoba.ca.; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia. cedric.tremblay@umanitoba.ca.<br /><searchLink fieldCode="AU" term="%22Saw+J%22">Saw J</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Yan+F%22">Yan F</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Bioinformatics Division, Walter and Eliza Hall Institute (WEHI) of Medical Research, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Boyle+JA%22">Boyle JA</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Amarasinghe+O%22">Amarasinghe O</searchLink>; Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.; Paul Albrechtsen Research Institute CancerCare Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Abdollahi+S%22">Abdollahi S</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Vo+ANQ%22">Vo ANQ</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Shields+BJ%22">Shields BJ</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mayoh+C%22">Mayoh C</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22McCalmont+H%22">McCalmont H</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Evans+K%22">Evans K</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Steiner+A%22">Steiner A</searchLink>; Paul Albrechtsen Research Institute CancerCare Manitoba, Winnipeg, MB, Canada.; Community and Researcher Engagement (CaRE) program, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Women in Lymphoma, Lymphoma Australia, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Parsons+K%22">Parsons K</searchLink>; Community and Researcher Engagement (CaRE) program, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22McCormack+MP%22">McCormack MP</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Powell+DR%22">Powell DR</searchLink>; Monash Bioinformatics Platform, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+NC%22">Wong NC</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Monash Bioinformatics Platform, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jane+SM%22">Jane SM</searchLink>; Department of Medicine, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Curtis+DJ%22">Curtis DJ</searchLink>; Australian Centre for Blood Diseases (ACBD), School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Department of Clinical Haematology, Alfred Hospital, Prahran, VIC, Australia.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2025 Mar; Vol. 39 (3), pp. 577-589. <i>Date of Electronic Publication: </i>2025 Jan 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE
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              Text: 2025 Mar
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