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Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice.

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Title: Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice.
Authors: Kisakov DN; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Karpenko LI; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Kisakova LA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Sharabrin SV; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Borgoyakova MB; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Starostina EV; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Taranov OS; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Ivleva EK; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Pyankov OV; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Zaykovskaya AV; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Dmitrienko EV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia., Yakovlev VA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Tigeeva EV; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Bauer IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia., Krasnikova SI; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Rudometova NB; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Rudometov AP; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Sergeev AA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia., Ilyichev AA; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.
Source: Vaccines [Vaccines (Basel)] 2025 Jan 13; Vol. 13 (1). Date of Electronic Publication: 2025 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice.
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  Data: <searchLink fieldCode="AU" term="%22Kisakov+DN%22">Kisakov DN</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Karpenko+LI%22">Karpenko LI</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Kisakova+LA%22">Kisakova LA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Sharabrin+SV%22">Sharabrin SV</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Borgoyakova+MB%22">Borgoyakova MB</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Starostina+EV%22">Starostina EV</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Taranov+OS%22">Taranov OS</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Ivleva+EK%22">Ivleva EK</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Pyankov+OV%22">Pyankov OV</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Zaykovskaya+AV%22">Zaykovskaya AV</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Dmitrienko+EV%22">Dmitrienko EV</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Yakovlev+VA%22">Yakovlev VA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Tigeeva+EV%22">Tigeeva EV</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Bauer+IA%22">Bauer IA</searchLink>; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia.<br /><searchLink fieldCode="AU" term="%22Krasnikova+SI%22">Krasnikova SI</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Rudometova+NB%22">Rudometova NB</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Rudometov+AP%22">Rudometov AP</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Sergeev+AA%22">Sergeev AA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.<br /><searchLink fieldCode="AU" term="%22Ilyichev+AA%22">Ilyichev AA</searchLink>; State Research Center of Virology and Biotechnology 'Vector', Rospotrebnadzor, World-Class Genomic Research Center for Biological Safety and Technological Independence, Federal Scientific and Technical Program on the Development of Genetic Technologies, 630559 Koltsovo, Russia.
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  Data: <searchLink fieldCode="JN" term="%22101629355%22">Vaccines</searchLink> [Vaccines (Basel)] 2025 Jan 13; Vol. 13 (1). <i>Date of Electronic Publication: </i>2025 Jan 13.
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        Value: 10.3390/vaccines13010065
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