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A tough soft-hard interface in the human knee joint driven by multiscale toughening mechanisms.

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Title: A tough soft-hard interface in the human knee joint driven by multiscale toughening mechanisms.
Authors: Li W; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Wang X; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Mao R; Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China., Li D; School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore., Meng H; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Zhang R; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Fang J; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China., Kang Z; Beijing Life Science Academy, Beijing 102200, China., Wu B; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Ma W; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Yao X; International lnstitutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China., Xie C; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Li R; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Wang J; School of Materials Science and Engineering, Zhejiang University, Hangzhou 310058, China., Chen X; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Pan X; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China., Chen W; Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China., Duan W; Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China., Gao H; Mechano-X Institute, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China., Ouyang H; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jan 28; Vol. 122 (4), pp. e2416085122. Date of Electronic Publication: 2025 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Mao+R%22">Mao R</searchLink>; Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.<br /><searchLink fieldCode="AU" term="%22Meng+H%22">Meng H</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Fang+J%22">Fang J</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.<br /><searchLink fieldCode="AU" term="%22Kang+Z%22">Kang Z</searchLink>; Beijing Life Science Academy, Beijing 102200, China.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Ma+W%22">Ma W</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; International lnstitutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu 322000, China.<br /><searchLink fieldCode="AU" term="%22Xie+C%22">Xie C</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; School of Materials Science and Engineering, Zhejiang University, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Pan+X%22">Pan X</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.<br /><searchLink fieldCode="AU" term="%22Duan+W%22">Duan W</searchLink>; Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Mechano-X Institute, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.<br /><searchLink fieldCode="AU" term="%22Ouyang+H%22">Ouyang H</searchLink>; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311113, China.; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 314400, China.; China Orthopedic Regenerative Medicine Group, Hangzhou 310058, China.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Jan 28; Vol. 122 (4), pp. e2416085122. <i>Date of Electronic Publication: </i>2025 Jan 24.
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