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Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition.

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Title: Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition.
Authors: Li H; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA., Furusawa T; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA., Cavero R; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA., Xiao Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA., Chari R; Genome Modification Core, Laboratory Animal Sciences Program, Frederick, MD, USA., Wu X; NCI Genomics Technology Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research/ Frederick, Maryland, USA., Sun D; NCI Genomics Technology Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research/ Frederick, Maryland, USA., Hartmann O; Comprehensive Pneumology Center (CPC)/Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the German Center for Lung Research (DZL/CPC-M), Munich, Germany., Dhall A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA., Holewinski R; Protein Characterization Laboratory/Cancer Research Technology Program/Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Andresson T; Protein Characterization Laboratory/Cancer Research Technology Program/Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Karim B; Molecular Histopathology Laboratory/ Cancer Research Technology Program/Frederick National Laboratory for Cancer Research/ Frederick, Maryland, USA., Villamor-Payà M; Radiation Oncology Branch/CCR/NCI, USA., Gallardo D; Laboratory Animal Sciences Program, Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Day CP; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA., Pal LR; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA., Nair NU; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA., Ruppin E; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA., Aladjem MI; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA., Pommier Y; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA., Diefenbacher ME; Comprehensive Pneumology Center (CPC)/Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the German Center for Lung Research (DZL/CPC-M), Munich, Germany., Lim JM; Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Levine RL; Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Stracker TH; Radiation Oncology Branch/CCR/NCI, USA., Weyemi U; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA. Electronic address: urbain.weyemi@nih.gov.
Source: Redox biology [Redox Biol] 2025 Mar; Vol. 80, pp. 103503. Date of Electronic Publication: 2025 Jan 19.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA.<br /><searchLink fieldCode="AU" term="%22Furusawa+T%22">Furusawa T</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Cavero+R%22">Cavero R</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Chari+R%22">Chari R</searchLink>; Genome Modification Core, Laboratory Animal Sciences Program, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; NCI Genomics Technology Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research/ Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; NCI Genomics Technology Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research/ Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hartmann+O%22">Hartmann O</searchLink>; Comprehensive Pneumology Center (CPC)/Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the German Center for Lung Research (DZL/CPC-M), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dhall+A%22">Dhall A</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Holewinski+R%22">Holewinski R</searchLink>; Protein Characterization Laboratory/Cancer Research Technology Program/Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Andresson+T%22">Andresson T</searchLink>; Protein Characterization Laboratory/Cancer Research Technology Program/Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Karim+B%22">Karim B</searchLink>; Molecular Histopathology Laboratory/ Cancer Research Technology Program/Frederick National Laboratory for Cancer Research/ Frederick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Villamor-Payà+M%22">Villamor-Payà M</searchLink>; Radiation Oncology Branch/CCR/NCI, USA.<br /><searchLink fieldCode="AU" term="%22Gallardo+D%22">Gallardo D</searchLink>; Laboratory Animal Sciences Program, Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Day+CP%22">Day CP</searchLink>; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Pal+LR%22">Pal LR</searchLink>; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Nair+NU%22">Nair NU</searchLink>; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ruppin+E%22">Ruppin E</searchLink>; Cancer Data Science Lab/ Center for Cancer Research/National Cancer Institute/National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Aladjem+MI%22">Aladjem MI</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Pommier+Y%22">Pommier Y</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Diefenbacher+ME%22">Diefenbacher ME</searchLink>; Comprehensive Pneumology Center (CPC)/Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the German Center for Lung Research (DZL/CPC-M), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lim+JM%22">Lim JM</searchLink>; Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Levine+RL%22">Levine RL</searchLink>; Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Stracker+TH%22">Stracker TH</searchLink>; Radiation Oncology Branch/CCR/NCI, USA.<br /><searchLink fieldCode="AU" term="%22Weyemi+U%22">Weyemi U</searchLink>; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 37 Convent Drive, Bethesda, MD, 20892, USA. Electronic address: urbain.weyemi@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2025 Mar; Vol. 80, pp. 103503. <i>Date of Electronic Publication: </i>2025 Jan 19.
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