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Germline Single-Nucleotide Polymorphism GFI1-36N Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia.

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Title: Germline Single-Nucleotide Polymorphism GFI1-36N Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia.
Authors: Vorwerk J; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany., Liu L; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.; Department of Hematology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China., Stadler TH; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany., Frank D; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany., Ahmed HMM; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany., Patnana PK; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany., Kebenko M; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany., Dazert E; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany., Opalka B; Department of Hematology and Stem Cell Transplantation, West German Cancer Center Essen-Münster (WTZ), University Hospital Essen, 45147 Essen, Germany., von Bubnoff N; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany., Khandanpour C; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.
Source: Biomedicines [Biomedicines] 2025 Jan 05; Vol. 13 (1). Date of Electronic Publication: 2025 Jan 05.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Germline Single-Nucleotide Polymorphism GFI1-36N Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Vorwerk+J%22">Vorwerk J</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.; Department of Hematology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China.<br /><searchLink fieldCode="AU" term="%22Stadler+TH%22">Stadler TH</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Frank+D%22">Frank D</searchLink>; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Ahmed+HMM%22">Ahmed HMM</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Patnana+PK%22">Patnana PK</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Kebenko+M%22">Kebenko M</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Dazert+E%22">Dazert E</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Opalka+B%22">Opalka B</searchLink>; Department of Hematology and Stem Cell Transplantation, West German Cancer Center Essen-Münster (WTZ), University Hospital Essen, 45147 Essen, Germany.<br /><searchLink fieldCode="AU" term="%22von+Bubnoff+N%22">von Bubnoff N</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Khandanpour+C%22">Khandanpour C</searchLink>; Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, 23562 Lübeck, Germany.; Department of Hematology, Hemostaseology, Oncology, and Pneumology, West German Cancer Center Essen-Münster (WTZ), University Hospital Münster, 49149 Münster, Germany.
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