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IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.

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Title: IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.
Authors: Pohly MF; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Putzker K; Chemical Biology Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Scheinost S; Molecular Therapy in Hematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Centre, Heidelberg, Germany., Ben Taarit L; Molecular Therapy in Hematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Centre, Heidelberg, Germany., Walther T; Molecular Therapy in Hematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Centre, Heidelberg, Germany., Kummer S; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Wertheimer T; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Lin M; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Do THL; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Handler K; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Michler J; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Kivioja J; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland., Bach K; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Kisele S; Department of Pediatric Oncology, University Children's Hospital, University of Zurich, Zurich, Switzerland., Kim J; Department of Pediatric Oncology, University Children's Hospital, University of Zurich, Zurich, Switzerland., Dietrich S; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Department of Hematology, Oncology and Clinical Immunology, University Hospital of Düsseldorf, Düsseldorf, Germany., Bornhauser B; Department of Pediatric Oncology, University Children's Hospital, University of Zurich, Zurich, Switzerland., Wong WW; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Becher B; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Moor A; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Lewis J; Chemical Biology Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.; Anavo Therapeutics, Heidelberg, Germany., Ficht X; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Lu J; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany., Huber W; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany., Zenz T; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.
Source: Blood [Blood] 2025 May 15; Vol. 145 (20), pp. 2336-2352.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.
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  Data: <searchLink fieldCode="AU" term="%22Pohly+MF%22">Pohly MF</searchLink>; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Putzker+K%22">Putzker K</searchLink>; Chemical Biology Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Scheinost+S%22">Scheinost S</searchLink>; Molecular Therapy in Hematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Centre, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ben+Taarit+L%22">Ben Taarit L</searchLink>; Molecular Therapy in Hematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Centre, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Walther+T%22">Walther T</searchLink>; Molecular Therapy in Hematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Centre, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kummer+S%22">Kummer S</searchLink>; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wertheimer+T%22">Wertheimer T</searchLink>; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Do+THL%22">Do THL</searchLink>; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Handler+K%22">Handler K</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Michler+J%22">Michler J</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kivioja+J%22">Kivioja J</searchLink>; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bach+K%22">Bach K</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kisele+S%22">Kisele S</searchLink>; Department of Pediatric Oncology, University Children's Hospital, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Pediatric Oncology, University Children's Hospital, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dietrich+S%22">Dietrich S</searchLink>; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Department of Hematology, Oncology and Clinical Immunology, University Hospital of Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; Department of Pediatric Oncology, University Children's Hospital, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wong+WW%22">Wong WW</searchLink>; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Becher+B%22">Becher B</searchLink>; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moor+A%22">Moor A</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lewis+J%22">Lewis J</searchLink>; Chemical Biology Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.; Anavo Therapeutics, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ficht+X%22">Ficht X</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Huber+W%22">Huber W</searchLink>; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Molecular Medicine Partnership Unit, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zenz+T%22">Zenz T</searchLink>; Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.
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