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Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients.

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Title: Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients.
Authors: Martin-Inaraja M; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain., Romayor I; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., de Cámara AS; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain., Herrera L; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Palacios A; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain., Villaverde M; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain., Santos S; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Vesga MÁ; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Barreña B; Genetics Unit, Hospital de Basurto, Bilbao, Spain., Aransay AM; Genomic Analysis Platform, CIC Biogune-BRTA, Derio 48160, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid 28029, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Anguita J; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio 48160, Spain; Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Solorzano E; Biobizkaia Health Research Institute. Cruces University Hospital, Pediatric Surgery Department, Barakaldo, Spain., Prieto MB; Biobizkaia Health Research Institute. Cruces University Hospital, Department of Obstetrics and Gynecology, Human Reproduction Unit, Barakaldo 48903-Basque Country University. IVI Bilbao, IVIRMA, Leioa, Vizcaya, Spain., Matorras R; Biobizkaia Health Research Institute. Cruces University Hospital, Department of Obstetrics and Gynecology, Human Reproduction Unit, Barakaldo 48903-Basque Country University. IVI Bilbao, IVIRMA, Leioa, Vizcaya, Spain., Eguizabal C; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: CRISTINA.EGUIZABALARGAIZ@bio-bizkaia.eus.
Source: Stem cell research [Stem Cell Res] 2025 Mar; Vol. 83, pp. 103657. Date of Electronic Publication: 2025 Jan 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE
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  Data: Generation, establishment and characterization of three pluripotent stem cell lines (CVTTHi002-A, CVTTHi003-A and CVTTHi004-A) from primary testicular somatic cells isolated from two prepuberal and one peripuberal Klinefelter Syndrome (47 XXY) patients.
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  Data: <searchLink fieldCode="AU" term="%22Martin-Inaraja+M%22">Martin-Inaraja M</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.<br /><searchLink fieldCode="AU" term="%22Romayor+I%22">Romayor I</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Cámara+AS%22">de Cámara AS</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.<br /><searchLink fieldCode="AU" term="%22Herrera+L%22">Herrera L</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Palacios+A%22">Palacios A</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.<br /><searchLink fieldCode="AU" term="%22Villaverde+M%22">Villaverde M</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.<br /><searchLink fieldCode="AU" term="%22Santos+S%22">Santos S</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vesga+MÁ%22">Vesga MÁ</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Barreña+B%22">Barreña B</searchLink>; Genetics Unit, Hospital de Basurto, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Aransay+AM%22">Aransay AM</searchLink>; Genomic Analysis Platform, CIC Biogune-BRTA, Derio 48160, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid 28029, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Anguita+J%22">Anguita J</searchLink>; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio 48160, Spain; Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Solorzano+E%22">Solorzano E</searchLink>; Biobizkaia Health Research Institute. Cruces University Hospital, Pediatric Surgery Department, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Prieto+MB%22">Prieto MB</searchLink>; Biobizkaia Health Research Institute. Cruces University Hospital, Department of Obstetrics and Gynecology, Human Reproduction Unit, Barakaldo 48903-Basque Country University. IVI Bilbao, IVIRMA, Leioa, Vizcaya, Spain.<br /><searchLink fieldCode="AU" term="%22Matorras+R%22">Matorras R</searchLink>; Biobizkaia Health Research Institute. Cruces University Hospital, Department of Obstetrics and Gynecology, Human Reproduction Unit, Barakaldo 48903-Basque Country University. IVI Bilbao, IVIRMA, Leioa, Vizcaya, Spain.<br /><searchLink fieldCode="AU" term="%22Eguizabal+C%22">Eguizabal C</searchLink>; Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute Barakaldo, Spain; Advanced Therapies Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain; Red Española de Terapias Avanzadas (TERAV), Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS RD21/0017/0024, RD24/0014/0025), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: CRISTINA.EGUIZABALARGAIZ@bio-bizkaia.eus.
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