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Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.

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Title: Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.
Authors: Mettu A; University of Missouri - Columbia, Department of Chemistry USA dmitri.kireev@missouri.edu., Glavatskikh M; University of North Carolina at Chapel Hill, Center for Integrative Chemical Biology and Drug Discovery USA., Wang X; University of Missouri - Columbia, Department of Chemistry USA dmitri.kireev@missouri.edu., Lara Ordóñez AJ; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - LilNCog - Lille Neuroscience & Cognition F-59000 France., Li F; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Chau I; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Ackloo S; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Arrowsmith C; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Medical Biophysics, University of Toronto Toronto Ontario M5G 1L7 Canada.; Princess Margaret Cancer Centre, University Health Network Toronto Ontario M5G 2C4 Canada., Bolotokova A; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Ghiabi P; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Gibson E; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Halabelian L; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Department of Pharmacology and Toxicology, University of Toronto Toronto Ontario M5S 1A8 Canada., Houliston S; Princess Margaret Cancer Centre, University Health Network Toronto Ontario M5G 2C4 Canada., Harding RJ; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Department of Pharmacology and Toxicology, University of Toronto Toronto Ontario M5S 1A8 Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto Toronto Ontario M5S 3M2 Canada., Hutchinson A; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Loppnau P; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Perveen S; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Seitova A; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Zeng H; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada., Schapira M; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Department of Pharmacology and Toxicology, University of Toronto Toronto Ontario M5S 1A8 Canada., Taymans JM; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - LilNCog - Lille Neuroscience & Cognition F-59000 France., Kireev D; University of Missouri - Columbia, Department of Chemistry USA dmitri.kireev@missouri.edu.; University of North Carolina at Chapel Hill, Center for Integrative Chemical Biology and Drug Discovery USA.
Source: Chemical science [Chem Sci] 2025 Jan 09; Vol. 16 (8), pp. 3430-3439. Date of Electronic Publication: 2025 Jan 09 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mettu+A%22">Mettu A</searchLink>; University of Missouri - Columbia, Department of Chemistry USA dmitri.kireev@missouri.edu.<br /><searchLink fieldCode="AU" term="%22Glavatskikh+M%22">Glavatskikh M</searchLink>; University of North Carolina at Chapel Hill, Center for Integrative Chemical Biology and Drug Discovery USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; University of Missouri - Columbia, Department of Chemistry USA dmitri.kireev@missouri.edu.<br /><searchLink fieldCode="AU" term="%22Lara+Ordóñez+AJ%22">Lara Ordóñez AJ</searchLink>; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - LilNCog - Lille Neuroscience & Cognition F-59000 France.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Chau+I%22">Chau I</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Ackloo+S%22">Ackloo S</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Arrowsmith+C%22">Arrowsmith C</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Medical Biophysics, University of Toronto Toronto Ontario M5G 1L7 Canada.; Princess Margaret Cancer Centre, University Health Network Toronto Ontario M5G 2C4 Canada.<br /><searchLink fieldCode="AU" term="%22Bolotokova+A%22">Bolotokova A</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Ghiabi+P%22">Ghiabi P</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Gibson+E%22">Gibson E</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Halabelian+L%22">Halabelian L</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Department of Pharmacology and Toxicology, University of Toronto Toronto Ontario M5S 1A8 Canada.<br /><searchLink fieldCode="AU" term="%22Houliston+S%22">Houliston S</searchLink>; Princess Margaret Cancer Centre, University Health Network Toronto Ontario M5G 2C4 Canada.<br /><searchLink fieldCode="AU" term="%22Harding+RJ%22">Harding RJ</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Department of Pharmacology and Toxicology, University of Toronto Toronto Ontario M5S 1A8 Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto Toronto Ontario M5S 3M2 Canada.<br /><searchLink fieldCode="AU" term="%22Hutchinson+A%22">Hutchinson A</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Loppnau+P%22">Loppnau P</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Perveen+S%22">Perveen S</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Seitova+A%22">Seitova A</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.<br /><searchLink fieldCode="AU" term="%22Schapira+M%22">Schapira M</searchLink>; Structural Genomics Consortium, University of Toronto Toronto ON M5G 1L7 Canada.; Department of Pharmacology and Toxicology, University of Toronto Toronto Ontario M5S 1A8 Canada.<br /><searchLink fieldCode="AU" term="%22Taymans+JM%22">Taymans JM</searchLink>; Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - LilNCog - Lille Neuroscience & Cognition F-59000 France.<br /><searchLink fieldCode="AU" term="%22Kireev+D%22">Kireev D</searchLink>; University of Missouri - Columbia, Department of Chemistry USA dmitri.kireev@missouri.edu.; University of North Carolina at Chapel Hill, Center for Integrative Chemical Biology and Drug Discovery USA.
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  Data: <searchLink fieldCode="JN" term="%22101545951%22">Chemical science</searchLink> [Chem Sci] 2025 Jan 09; Vol. 16 (8), pp. 3430-3439. <i>Date of Electronic Publication: </i>2025 Jan 09 (<i>Print Publication: </i>2025).
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