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Solving unknown primary cancer with earlier diagnosis - the SUPER-ED trial: study protocol for a stepped-wedge cluster randomised controlled trial to support earlier diagnosis for people presenting with malignancy of undefined primary origin.

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Title: Solving unknown primary cancer with earlier diagnosis - the SUPER-ED trial: study protocol for a stepped-wedge cluster randomised controlled trial to support earlier diagnosis for people presenting with malignancy of undefined primary origin.
Authors: Ugalde A; Institute for Health Transformation, Faculty of Health, Deakin University, 221 Burwood Highway, Burwood, Geelong, Victoria, 3125, Australia. a.ugalde@deakin.edu.au., Tothill RW; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Clinical Pathology and Centre for Cancer Research, University of Melbourne, Parkville, Victoria, Australia., Quinn S; Swinburne University of Technology, Hawthorn, Victoria, Australia., Wong HL; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Prall O; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia., Mitchell C; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Wickramasinghe N; Swinburne University of Technology, Hawthorn, Victoria, Australia.; Latrobe University, Bundoora, Victoria, Australia., Fedele C; CSL Innovation, Melbourne, Victoria, Australia., Richards N; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia., Todio E; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Swinburne University of Technology, Hawthorn, Victoria, Australia., Bryant C; Swinburne University of Technology, Hawthorn, Victoria, Australia., Collins LG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Viertel Cancer Research Centre, Cancer Council Queensland, Queensland, Australia., McLean S; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia., Ko HS; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia.; Department of Diagnostic and interventional Radiology, University Hospital Bonn, Bonn, Germany., Akhurst T; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia., Steer C; Border Medical Oncology, Albury Wodonga Regional Cancer Centre, Albury, New South Wales, Australia., Gao B; University of Sydney, Sydney, New South Wales, Australia.; Department of Medical Oncology, Westmead Hospital, Sydney, New South Wales, Australia., Wong M; Department of Medical Oncology, Westmead Hospital, Sydney, New South Wales, Australia., Georgiou C; Department of Medical Oncology, Bendigo Health, Bendigo, Victoria, Australia., Karanth N; Department of Medical Oncology, Royal Darwin Hospital, Darwin, Northern Territory, Australia., Kuchel A; University of Queensland, Brisbane, Queensland, Australia., Nott L; Department of Medical Oncology, Royal Hobart Hospital, Hobart, Tasmania, Australia., Padinharakam S; Launceston General Hospital, Launceston, Tasmania, Australia., Shackleton M; Department of Oncology, Alfred Hospital, Melbourne, Victoria, Australia.; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Collins IM; Institute for Health Transformation, Faculty of Health, Deakin University, 221 Burwood Highway, Burwood, Geelong, Victoria, 3125, Australia.; Southwest Healthcare, Warrnambool, Victoria, Australia., Singh M; Barwon Health, Geelong, Victoria, Australia., Wong R; Eastern Health, Melbourne, Victoria, Australia., Wong ZW; Monash Health, Clayton, Victoria, Australia., Butler A; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia., Sivakumaran T; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Schofield P; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Swinburne University of Technology, Hawthorn, Victoria, Australia.; School of Computing, Engineering and Mathematical Sciences, La Trobe University, Melbourne, Australia., Mileshkin L; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
Source: BMC cancer [BMC Cancer] 2025 Jan 29; Vol. 25 (1), pp. 171. Date of Electronic Publication: 2025 Jan 29.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Solving unknown primary cancer with earlier diagnosis - the SUPER-ED trial: study protocol for a stepped-wedge cluster randomised controlled trial to support earlier diagnosis for people presenting with malignancy of undefined primary origin.
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  Data: <searchLink fieldCode="AU" term="%22Ugalde+A%22">Ugalde A</searchLink>; Institute for Health Transformation, Faculty of Health, Deakin University, 221 Burwood Highway, Burwood, Geelong, Victoria, 3125, Australia. a.ugalde@deakin.edu.au.<br /><searchLink fieldCode="AU" term="%22Tothill+RW%22">Tothill RW</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Clinical Pathology and Centre for Cancer Research, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Quinn+S%22">Quinn S</searchLink>; Swinburne University of Technology, Hawthorn, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+HL%22">Wong HL</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Prall+O%22">Prall O</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Mitchell+C%22">Mitchell C</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wickramasinghe+N%22">Wickramasinghe N</searchLink>; Swinburne University of Technology, Hawthorn, Victoria, Australia.; Latrobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fedele+C%22">Fedele C</searchLink>; CSL Innovation, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Richards+N%22">Richards N</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Todio+E%22">Todio E</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Swinburne University of Technology, Hawthorn, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Bryant+C%22">Bryant C</searchLink>; Swinburne University of Technology, Hawthorn, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Collins+LG%22">Collins LG</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Viertel Cancer Research Centre, Cancer Council Queensland, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22McLean+S%22">McLean S</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ko+HS%22">Ko HS</searchLink>; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia.; Department of Diagnostic and interventional Radiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Akhurst+T%22">Akhurst T</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Steer+C%22">Steer C</searchLink>; Border Medical Oncology, Albury Wodonga Regional Cancer Centre, Albury, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gao+B%22">Gao B</searchLink>; University of Sydney, Sydney, New South Wales, Australia.; Department of Medical Oncology, Westmead Hospital, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+M%22">Wong M</searchLink>; Department of Medical Oncology, Westmead Hospital, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Georgiou+C%22">Georgiou C</searchLink>; Department of Medical Oncology, Bendigo Health, Bendigo, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Karanth+N%22">Karanth N</searchLink>; Department of Medical Oncology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.<br /><searchLink fieldCode="AU" term="%22Kuchel+A%22">Kuchel A</searchLink>; University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Nott+L%22">Nott L</searchLink>; Department of Medical Oncology, Royal Hobart Hospital, Hobart, Tasmania, Australia.<br /><searchLink fieldCode="AU" term="%22Padinharakam+S%22">Padinharakam S</searchLink>; Launceston General Hospital, Launceston, Tasmania, Australia.<br /><searchLink fieldCode="AU" term="%22Shackleton+M%22">Shackleton M</searchLink>; Department of Oncology, Alfred Hospital, Melbourne, Victoria, Australia.; School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Collins+IM%22">Collins IM</searchLink>; Institute for Health Transformation, Faculty of Health, Deakin University, 221 Burwood Highway, Burwood, Geelong, Victoria, 3125, Australia.; Southwest Healthcare, Warrnambool, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Barwon Health, Geelong, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+R%22">Wong R</searchLink>; Eastern Health, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+ZW%22">Wong ZW</searchLink>; Monash Health, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Butler+A%22">Butler A</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sivakumaran+T%22">Sivakumaran T</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Schofield+P%22">Schofield P</searchLink>; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Swinburne University of Technology, Hawthorn, Victoria, Australia.; School of Computing, Engineering and Mathematical Sciences, La Trobe University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Mileshkin+L%22">Mileshkin L</searchLink>; Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
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  Data: <searchLink fieldCode="JN" term="%22100967800%22">BMC cancer</searchLink> [BMC Cancer] 2025 Jan 29; Vol. 25 (1), pp. 171. <i>Date of Electronic Publication: </i>2025 Jan 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100967800 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-2407 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214712407%22">14712407 </searchLink><i>NLM ISO Abbreviation: </i>BMC Cancer <i>Subsets: </i>MEDLINE
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              Text: 2025 Jan 29
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